Healthy-like CD4<sup>+</sup> Regulatory and CD4<sup>+</sup> Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion

Healthy-like CD4<sup>+</sup> Regulatory and CD4<sup>+</sup> Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion

Donor lymphocyte infusion (DLI) can (re-)induce durable remission in relapsing patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). However, DLI harbors the risk of increased non-relapse mortality due to the co-occurrence of graft-versus-host disease (GVHD). GVHD onset may b...

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Bibliographic Details
Main Authors: Jessica Schneider, Leonie Kuhlmann, Yankai Xiao, Solaiman Raha, Günter Bernhardt, Michael Stadler, Felicitas Thol, Michael Heuser, Matthias Eder, Arnold Ganser, Sarina Ravens, Reinhold Förster, Immo Prinz, Christian Koenecke, Christian R. Schultze-Florey
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
donor lymphocyte infusion
immunotherapy
graft-versus-host disease
allogeneic hematopoietic stem-cell transplantation
T<sub>reg</sub> cells
<i>TRB</i> sequencing
Online Access:https://www.mdpi.com/1422-0067/23/18/10914

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https://www.mdpi.com/1422-0067/23/18/10914

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