Prefrontal synaptic activation during hippocampal memory reactivation
Summary: Cooperative reactivation of hippocampal and prefrontal neurons is considered crucial for mnemonic processes. To directly record synaptic substances supporting the interregional interactions, we develop concurrent spike recordings of hippocampal neuronal ensembles and whole-cell patch-clamp...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721001996 |
| _version_ | 1818417815888068608 |
|---|---|
| author | Yuya Nishimura Yuji Ikegaya Takuya Sasaki |
| author_facet | Yuya Nishimura Yuji Ikegaya Takuya Sasaki |
| author_sort | Yuya Nishimura |
| collection | DOAJ |
| description | Summary: Cooperative reactivation of hippocampal and prefrontal neurons is considered crucial for mnemonic processes. To directly record synaptic substances supporting the interregional interactions, we develop concurrent spike recordings of hippocampal neuronal ensembles and whole-cell patch-clamp recordings of medial prefrontal neurons in awake rats. We find that medial prefrontal neurons depolarize when hippocampal neurons synchronize. The depolarization in medial prefrontal neurons is larger when hippocampal place cells that encoded overlapping place fields and place cells that encoded a novel environment are synchronously reactivated. Our results suggest a functional circuit-synapse association that enables prefrontal neurons to read out specific memory traces from the hippocampus. |
| first_indexed | 2024-12-14T12:12:47Z |
| format | Article |
| id | doaj.art-d00f95826bc144608288187221edcc32 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-14T12:12:47Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-d00f95826bc144608288187221edcc322022-12-21T23:01:42ZengElsevierCell Reports2211-12472021-03-013412108885Prefrontal synaptic activation during hippocampal memory reactivationYuya Nishimura0Yuji Ikegaya1Takuya Sasaki2Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, 1-4 Yamadaoka, Suita City, Osaka 565-0871, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan; Corresponding authorSummary: Cooperative reactivation of hippocampal and prefrontal neurons is considered crucial for mnemonic processes. To directly record synaptic substances supporting the interregional interactions, we develop concurrent spike recordings of hippocampal neuronal ensembles and whole-cell patch-clamp recordings of medial prefrontal neurons in awake rats. We find that medial prefrontal neurons depolarize when hippocampal neurons synchronize. The depolarization in medial prefrontal neurons is larger when hippocampal place cells that encoded overlapping place fields and place cells that encoded a novel environment are synchronously reactivated. Our results suggest a functional circuit-synapse association that enables prefrontal neurons to read out specific memory traces from the hippocampus.http://www.sciencedirect.com/science/article/pii/S2211124721001996hippocampusprefrontal cortexpatch-clamp recordingsynchronizationplace cellsynapse |
| spellingShingle | Yuya Nishimura Yuji Ikegaya Takuya Sasaki Prefrontal synaptic activation during hippocampal memory reactivation Cell Reports hippocampus prefrontal cortex patch-clamp recording synchronization place cell synapse |
| title | Prefrontal synaptic activation during hippocampal memory reactivation |
| title_full | Prefrontal synaptic activation during hippocampal memory reactivation |
| title_fullStr | Prefrontal synaptic activation during hippocampal memory reactivation |
| title_full_unstemmed | Prefrontal synaptic activation during hippocampal memory reactivation |
| title_short | Prefrontal synaptic activation during hippocampal memory reactivation |
| title_sort | prefrontal synaptic activation during hippocampal memory reactivation |
| topic | hippocampus prefrontal cortex patch-clamp recording synchronization place cell synapse |
| url | http://www.sciencedirect.com/science/article/pii/S2211124721001996 |
| work_keys_str_mv | AT yuyanishimura prefrontalsynapticactivationduringhippocampalmemoryreactivation AT yujiikegaya prefrontalsynapticactivationduringhippocampalmemoryreactivation AT takuyasasaki prefrontalsynapticactivationduringhippocampalmemoryreactivation |