IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells
Although the expression of interleukin-2 receptor α-chain (IL-2Rα, CD25) has been provided prognostic significance independent of known biomarkers in acute myeloid leukemia (AML), the functional role of CD25 molecule remains unknown. Since IL-2 can be trans-presented via CD25 to another cell, CD25+A...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221304892400044X |
| _version_ | 1797260369997070336 |
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| author | Kazunori Nakase Kenkichi Kita |
| author_facet | Kazunori Nakase Kenkichi Kita |
| author_sort | Kazunori Nakase |
| collection | DOAJ |
| description | Although the expression of interleukin-2 receptor α-chain (IL-2Rα, CD25) has been provided prognostic significance independent of known biomarkers in acute myeloid leukemia (AML), the functional role of CD25 molecule remains unknown. Since IL-2 can be trans-presented via CD25 to another cell, CD25+AML cells may deliver environmental IL-2 to surrounding immune cells to produce myeloid growth factors for their proliferation. We hypothesize that cellular interactions via IL-2/CD25 axis in the bone marrow microenvironment contributes to the growth advantage of these AML cells and affects the clinical outcome of those AML patients. |
| first_indexed | 2024-04-24T23:24:14Z |
| format | Article |
| id | doaj.art-d0132fc5774242609da8dbab7cb4bcf1 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-24T23:24:14Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-d0132fc5774242609da8dbab7cb4bcf12024-03-16T05:08:23ZengElsevierLeukemia Research Reports2213-04892024-01-0121100454IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cellsKazunori Nakase0Kenkichi Kita1Department of Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan; Corresponding author.Department of Internal Medicine, Japan Baptist Hospital, Kyoto, JapanAlthough the expression of interleukin-2 receptor α-chain (IL-2Rα, CD25) has been provided prognostic significance independent of known biomarkers in acute myeloid leukemia (AML), the functional role of CD25 molecule remains unknown. Since IL-2 can be trans-presented via CD25 to another cell, CD25+AML cells may deliver environmental IL-2 to surrounding immune cells to produce myeloid growth factors for their proliferation. We hypothesize that cellular interactions via IL-2/CD25 axis in the bone marrow microenvironment contributes to the growth advantage of these AML cells and affects the clinical outcome of those AML patients.http://www.sciencedirect.com/science/article/pii/S221304892400044XCD25Interleukin-2Acute myeloid leukemiaBiomarker |
| spellingShingle | Kazunori Nakase Kenkichi Kita IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells Leukemia Research Reports CD25 Interleukin-2 Acute myeloid leukemia Biomarker |
| title | IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells |
| title_full | IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells |
| title_fullStr | IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells |
| title_full_unstemmed | IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells |
| title_short | IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells |
| title_sort | il 2 cd25 axis mediates cellular networks promoting the growth of cd25 acute myeloid leukemia cells |
| topic | CD25 Interleukin-2 Acute myeloid leukemia Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S221304892400044X |
| work_keys_str_mv | AT kazunorinakase il2cd25axismediatescellularnetworkspromotingthegrowthofcd25acutemyeloidleukemiacells AT kenkichikita il2cd25axismediatescellularnetworkspromotingthegrowthofcd25acutemyeloidleukemiacells |