ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/11/2271 |
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| author | Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen |
| author_facet | Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen |
| author_sort | Johanna Tietäväinen |
| collection | DOAJ |
| description | Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (<i>n</i> = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection. |
| first_indexed | 2024-03-10T04:59:34Z |
| format | Article |
| id | doaj.art-d0135eafa39a4ce982138a2866fae52e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:59:34Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d0135eafa39a4ce982138a2866fae52e2023-11-23T01:57:56ZengMDPI AGViruses1999-49152021-11-011311227110.3390/v13112271ABO and Rhesus Blood Groups in Acute Puumala Hantavirus InfectionJohanna Tietäväinen0Outi Laine1Satu Mäkelä2Heini Huhtala3Ilkka Pörsti4Antti Vaheri5Jukka Mustonen6Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandFaculty of Social Sciences, Tampere University, 33250 Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandDepartment of Virology, Medicum, University of Helsinki, 00290 Helsinki, FinlandFaculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandPuumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (<i>n</i> = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.https://www.mdpi.com/1999-4915/13/11/2271Puumala hantavirusABO blood groupsrhesus blood groupscapillary leakageAKIblood pressure |
| spellingShingle | Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection Viruses Puumala hantavirus ABO blood groups rhesus blood groups capillary leakage AKI blood pressure |
| title | ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection |
| title_full | ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection |
| title_fullStr | ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection |
| title_full_unstemmed | ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection |
| title_short | ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection |
| title_sort | abo and rhesus blood groups in acute puumala hantavirus infection |
| topic | Puumala hantavirus ABO blood groups rhesus blood groups capillary leakage AKI blood pressure |
| url | https://www.mdpi.com/1999-4915/13/11/2271 |
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