The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis

The dissemination of cancer cells from the primary tumor to a distant site, known as metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex cellular process that involves many steps, including the breaching of the basement membrane to allow the movement of cells...

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Main Authors: Abitha eJacob, Rytis ePrekeris
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00004/full
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author Abitha eJacob
Rytis ePrekeris
author_facet Abitha eJacob
Rytis ePrekeris
author_sort Abitha eJacob
collection DOAJ
description The dissemination of cancer cells from the primary tumor to a distant site, known as metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex cellular process that involves many steps, including the breaching of the basement membrane to allow the movement of cells through tissues. The basement membrane breach occurs via highly regulated and localized remodeling of the extracellular matrix (ECM), which is mediated by formation of structures, known as invadopodia, and targeted secretion of matrix metalloproteinases (MMPs). Recently, invadopodia have emerged as key cellular structures that regulate the metastasis of many cancers. Furthermore, targeting of various cytoskeletal modulators and MMPs has been shown to play a major role in regulating invadopodia function. Here, we highlight recent findings regarding the regulation of protein targeting during invadopodia formation and function.
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spelling doaj.art-d0152102d67b454fa08a6e07d31d41162022-12-22T02:25:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2015-02-01310.3389/fcell.2015.00004127875The Regulation of MMP Targeting to Invadopodia During Cancer MetastasisAbitha eJacob0Rytis ePrekeris1University of Colorado Anschutz Medical CampusUniversity of Colorado Anschutz Medical CampusThe dissemination of cancer cells from the primary tumor to a distant site, known as metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex cellular process that involves many steps, including the breaching of the basement membrane to allow the movement of cells through tissues. The basement membrane breach occurs via highly regulated and localized remodeling of the extracellular matrix (ECM), which is mediated by formation of structures, known as invadopodia, and targeted secretion of matrix metalloproteinases (MMPs). Recently, invadopodia have emerged as key cellular structures that regulate the metastasis of many cancers. Furthermore, targeting of various cytoskeletal modulators and MMPs has been shown to play a major role in regulating invadopodia function. Here, we highlight recent findings regarding the regulation of protein targeting during invadopodia formation and function.http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00004/fullCancermetastasisinvadopodiamembrane trafficMMP2MMP9
spellingShingle Abitha eJacob
Rytis ePrekeris
The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
Frontiers in Cell and Developmental Biology
Cancer
metastasis
invadopodia
membrane traffic
MMP2
MMP9
title The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
title_full The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
title_fullStr The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
title_full_unstemmed The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
title_short The Regulation of MMP Targeting to Invadopodia During Cancer Metastasis
title_sort regulation of mmp targeting to invadopodia during cancer metastasis
topic Cancer
metastasis
invadopodia
membrane traffic
MMP2
MMP9
url http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00004/full
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