Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats
ABSTRACT Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabe...
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Academia Brasileira de Ciências
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| author | MARCELO S. PINHEIRO LUHARA S. RODRIGUES LEILA S. NETO RAFAIANNE Q. MORAES-SOUZA THAIGRA S. SOARES MADILEINE F. AMÉRICO KLEBER E. CAMPOS DÉBORA C. DAMASCENO GUSTAVO T. VOLPATO |
| author_facet | MARCELO S. PINHEIRO LUHARA S. RODRIGUES LEILA S. NETO RAFAIANNE Q. MORAES-SOUZA THAIGRA S. SOARES MADILEINE F. AMÉRICO KLEBER E. CAMPOS DÉBORA C. DAMASCENO GUSTAVO T. VOLPATO |
| author_sort | MARCELO S. PINHEIRO |
| collection | DOAJ |
| description | ABSTRACT Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness. |
| first_indexed | 2024-12-10T23:09:35Z |
| format | Article |
| id | doaj.art-d015631f5f234733bf8d41f71f5de1dc |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-10T23:09:35Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-d015631f5f234733bf8d41f71f5de1dc2022-12-22T01:29:59ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-2690010.1590/0001-3765201720160050S0001-37652017005003101Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic ratsMARCELO S. PINHEIROLUHARA S. RODRIGUESLEILA S. NETORAFAIANNE Q. MORAES-SOUZATHAIGRA S. SOARESMADILEINE F. AMÉRICOKLEBER E. CAMPOSDÉBORA C. DAMASCENOGUSTAVO T. VOLPATOABSTRACT Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017005003101&lng=en&tlng=enBauhinia holophylladiabeteslipid profilemedicinal plantsrats. |
| spellingShingle | MARCELO S. PINHEIRO LUHARA S. RODRIGUES LEILA S. NETO RAFAIANNE Q. MORAES-SOUZA THAIGRA S. SOARES MADILEINE F. AMÉRICO KLEBER E. CAMPOS DÉBORA C. DAMASCENO GUSTAVO T. VOLPATO Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats Anais da Academia Brasileira de Ciências Bauhinia holophylla diabetes lipid profile medicinal plants rats. |
| title | Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats |
| title_full | Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats |
| title_fullStr | Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats |
| title_full_unstemmed | Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats |
| title_short | Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats |
| title_sort | effect of bauhinia holophylla treatment in streptozotocin induced diabetic rats |
| topic | Bauhinia holophylla diabetes lipid profile medicinal plants rats. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017005003101&lng=en&tlng=en |
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