Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats
Diabetic peripheral neuropathy (DPN) is considered as one of the most important complications of diabetes mellitus. At present, effective treatments that might improve the damaged neurological function in DPN are sorely needed. As myricetin has been proved to possess excellent neuroprotective and an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.915603/full |
| _version_ | 1818473682194923520 |
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| author | Junxiong Ma Jun Liu Yu Chen Hailong Yu Liangbi Xiang |
| author_facet | Junxiong Ma Jun Liu Yu Chen Hailong Yu Liangbi Xiang |
| author_sort | Junxiong Ma |
| collection | DOAJ |
| description | Diabetic peripheral neuropathy (DPN) is considered as one of the most important complications of diabetes mellitus. At present, effective treatments that might improve the damaged neurological function in DPN are sorely needed. As myricetin has been proved to possess excellent neuroprotective and antioxidant effects, it might have therapeutic potential for DPN. Therefore, the purpose of our study was to detect the potential beneficial effect of myricetin on DPN. A single dose of 50 mg/kg of streptozotocin was applied in rats for the establishment of diabetic models. Different doses of myricetin (0.5 mg/kg/day, 1.0 mg/kg/day, and 2.0 mg/kg/day) were intraperitoneally injected for 2 weeks from the 21st day after streptozotocin injection. After the final myricetin injection, behavioral, electrophysiological, biochemical, and protein analyses were performed. In the present study, myricetin significantly ameliorated diabetes-induced impairment in sensation, nerve conduction velocities, and nerve blood flow. In addition, myricetin significantly reduced the generation of advanced glycation end-products (AGEs) and reactive oxygen species (ROS), and elevated Na+, K+-ATPase activity and antioxidant activities in nerves in diabetic animals. Additional studies revealed that myricetin significantly raised the hydrogen sulfide (H2S) levels, and elevated the expression level of heme oxygenase-1 (HO-1) as well as nuclear factor-E2-related factor-2 (Nrf2) in diabetic rats. In addition, myricetin has the capability of decreasing plasma glucose under diabetic conditions. The findings in our present study collectively indicated that myricetin could restore the impaired motor and sensory functions under diabetic conditions. The Nrf2-dependent antioxidant action and the capability of decreasing plasma glucose might be the underlying mechanisms for the beneficial effect of myricetin on impaired neural functions. Our study showed the therapeutic potential of myricetin in the management of DPN. |
| first_indexed | 2024-04-14T04:25:34Z |
| format | Article |
| id | doaj.art-d0160802416047dd9b86363efa2beed8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T04:25:34Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d0160802416047dd9b86363efa2beed82022-12-22T02:12:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.915603915603Myricetin Improves Impaired Nerve Functions in Experimental Diabetic RatsJunxiong MaJun LiuYu ChenHailong YuLiangbi XiangDiabetic peripheral neuropathy (DPN) is considered as one of the most important complications of diabetes mellitus. At present, effective treatments that might improve the damaged neurological function in DPN are sorely needed. As myricetin has been proved to possess excellent neuroprotective and antioxidant effects, it might have therapeutic potential for DPN. Therefore, the purpose of our study was to detect the potential beneficial effect of myricetin on DPN. A single dose of 50 mg/kg of streptozotocin was applied in rats for the establishment of diabetic models. Different doses of myricetin (0.5 mg/kg/day, 1.0 mg/kg/day, and 2.0 mg/kg/day) were intraperitoneally injected for 2 weeks from the 21st day after streptozotocin injection. After the final myricetin injection, behavioral, electrophysiological, biochemical, and protein analyses were performed. In the present study, myricetin significantly ameliorated diabetes-induced impairment in sensation, nerve conduction velocities, and nerve blood flow. In addition, myricetin significantly reduced the generation of advanced glycation end-products (AGEs) and reactive oxygen species (ROS), and elevated Na+, K+-ATPase activity and antioxidant activities in nerves in diabetic animals. Additional studies revealed that myricetin significantly raised the hydrogen sulfide (H2S) levels, and elevated the expression level of heme oxygenase-1 (HO-1) as well as nuclear factor-E2-related factor-2 (Nrf2) in diabetic rats. In addition, myricetin has the capability of decreasing plasma glucose under diabetic conditions. The findings in our present study collectively indicated that myricetin could restore the impaired motor and sensory functions under diabetic conditions. The Nrf2-dependent antioxidant action and the capability of decreasing plasma glucose might be the underlying mechanisms for the beneficial effect of myricetin on impaired neural functions. Our study showed the therapeutic potential of myricetin in the management of DPN.https://www.frontiersin.org/articles/10.3389/fendo.2022.915603/fullmyricetinDPNnociceptionoxidative stressNrf2 |
| spellingShingle | Junxiong Ma Jun Liu Yu Chen Hailong Yu Liangbi Xiang Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats Frontiers in Endocrinology myricetin DPN nociception oxidative stress Nrf2 |
| title | Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats |
| title_full | Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats |
| title_fullStr | Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats |
| title_full_unstemmed | Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats |
| title_short | Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats |
| title_sort | myricetin improves impaired nerve functions in experimental diabetic rats |
| topic | myricetin DPN nociception oxidative stress Nrf2 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.915603/full |
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