A role for p53 in telomere protection
Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1143078 |
| _version_ | 1797677240639553536 |
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| author | Stephen Tutton Paul M. Lieberman |
| author_facet | Stephen Tutton Paul M. Lieberman |
| author_sort | Stephen Tutton |
| collection | DOAJ |
| description | Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription activation and enhanced telomere stability in the presence of DNA damage. |
| first_indexed | 2024-03-11T22:42:12Z |
| format | Article |
| id | doaj.art-d0165b5f127a4c41872d4d626f2ba540 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:42:12Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-d0165b5f127a4c41872d4d626f2ba5402023-09-22T09:10:57ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-11-014610.1080/23723556.2016.11430781143078A role for p53 in telomere protectionStephen Tutton0Paul M. Lieberman1Gene Expression and Regulation, The Wistar InstituteGene Expression and Regulation, The Wistar InstituteTelomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription activation and enhanced telomere stability in the presence of DNA damage.http://dx.doi.org/10.1080/23723556.2016.1143078chromatindna-damageernatelomereterratp53yh2ax |
| spellingShingle | Stephen Tutton Paul M. Lieberman A role for p53 in telomere protection Molecular & Cellular Oncology chromatin dna-damage erna telomere terra tp53 yh2ax |
| title | A role for p53 in telomere protection |
| title_full | A role for p53 in telomere protection |
| title_fullStr | A role for p53 in telomere protection |
| title_full_unstemmed | A role for p53 in telomere protection |
| title_short | A role for p53 in telomere protection |
| title_sort | role for p53 in telomere protection |
| topic | chromatin dna-damage erna telomere terra tp53 yh2ax |
| url | http://dx.doi.org/10.1080/23723556.2016.1143078 |
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