Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes

Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes

Summary: Bacillus Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines worldwide. In addition to protection against tuberculosis, BCG confers a degree of non-specific protection against other infections by enhancing secondary immune responses to heterologous pathogens, termed “train...

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Bibliographic Details
Main Authors: Lingjia Kong, Simone J.C.F.M. Moorlag, Ariel Lefkovith, Bihua Li, Vasiliki Matzaraki, Liesbeth van Emst, Heather A. Kang, Isabel Latorre, Martin Jaeger, Leo A.B. Joosten, Mihai G. Netea, Ramnik J. Xavier
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
BCG vaccination
trained immunity
monocytes
cytokines
single-cell sequencing
humanin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721015102

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