Amyloid Proteins and Peripheral Neuropathy
Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory dis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1553 |
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| author | Mohammed M. H. Albariqi Sjoukje Engelsman Niels Eijkelkamp Jo W. M. Höppener |
| author_facet | Mohammed M. H. Albariqi Sjoukje Engelsman Niels Eijkelkamp Jo W. M. Höppener |
| author_sort | Mohammed M. H. Albariqi |
| collection | DOAJ |
| description | Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature—deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. Here, we will discuss how amyloid proteins contribute to peripheral neuropathy by reviewing the current understanding of pathogenic mechanisms in known inherited and acquired (usually rare) amyloid neuropathies. In addition, we will discuss the potential role of amyloid proteins in peripheral neuropathy in some common diseases, which are not (yet) considered as amyloid neuropathies. We conclude that there are many similarities in the molecular and cell biological defects caused by aggregation of the various amyloid proteins in these different diseases and propose a common pathogenic pathway for “peripheral amyloid neuropathies”. |
| first_indexed | 2024-03-10T18:52:43Z |
| format | Article |
| id | doaj.art-d01867af9fe84104bd1a7ab6a236a98e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:52:43Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d01867af9fe84104bd1a7ab6a236a98e2023-11-20T05:01:36ZengMDPI AGCells2073-44092020-06-0196155310.3390/cells9061553Amyloid Proteins and Peripheral NeuropathyMohammed M. H. Albariqi0Sjoukje Engelsman1Niels Eijkelkamp2Jo W. M. Höppener3Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The NetherlandsCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The NetherlandsCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The NetherlandsCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The NetherlandsPainful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature—deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. Here, we will discuss how amyloid proteins contribute to peripheral neuropathy by reviewing the current understanding of pathogenic mechanisms in known inherited and acquired (usually rare) amyloid neuropathies. In addition, we will discuss the potential role of amyloid proteins in peripheral neuropathy in some common diseases, which are not (yet) considered as amyloid neuropathies. We conclude that there are many similarities in the molecular and cell biological defects caused by aggregation of the various amyloid proteins in these different diseases and propose a common pathogenic pathway for “peripheral amyloid neuropathies”.https://www.mdpi.com/2073-4409/9/6/1553amyloid proteinsamyloidosistype 2 diabetes mellitusperipheral neuropathyamyloid neuropathieschronic pain |
| spellingShingle | Mohammed M. H. Albariqi Sjoukje Engelsman Niels Eijkelkamp Jo W. M. Höppener Amyloid Proteins and Peripheral Neuropathy Cells amyloid proteins amyloidosis type 2 diabetes mellitus peripheral neuropathy amyloid neuropathies chronic pain |
| title | Amyloid Proteins and Peripheral Neuropathy |
| title_full | Amyloid Proteins and Peripheral Neuropathy |
| title_fullStr | Amyloid Proteins and Peripheral Neuropathy |
| title_full_unstemmed | Amyloid Proteins and Peripheral Neuropathy |
| title_short | Amyloid Proteins and Peripheral Neuropathy |
| title_sort | amyloid proteins and peripheral neuropathy |
| topic | amyloid proteins amyloidosis type 2 diabetes mellitus peripheral neuropathy amyloid neuropathies chronic pain |
| url | https://www.mdpi.com/2073-4409/9/6/1553 |
| work_keys_str_mv | AT mohammedmhalbariqi amyloidproteinsandperipheralneuropathy AT sjoukjeengelsman amyloidproteinsandperipheralneuropathy AT nielseijkelkamp amyloidproteinsandperipheralneuropathy AT jowmhoppener amyloidproteinsandperipheralneuropathy |