Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case)
Purpose: to contribute to relief of metabolic disorders associated with hypoxia by including a succinate correcting tissue metabolism into the scheme of intensive care of acute severe methadone poisoning complicated by the crush syndrome.Materials and methods. We examined the dynamics of clinical ma...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2018-10-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1710 |
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| author | G. A. Livanov A. N. Lodyagin A. А. Razina S. I. Glushkov A. A. Ivanova E. V. Volchkova B. V. Batotsyrenov |
| author_facet | G. A. Livanov A. N. Lodyagin A. А. Razina S. I. Glushkov A. A. Ivanova E. V. Volchkova B. V. Batotsyrenov |
| author_sort | G. A. Livanov |
| collection | DOAJ |
| description | Purpose: to contribute to relief of metabolic disorders associated with hypoxia by including a succinate correcting tissue metabolism into the scheme of intensive care of acute severe methadone poisoning complicated by the crush syndrome.Materials and methods. We examined the dynamics of clinical manifestation of acute methadone poisoning complicated by crush syndrome: changes in clinical and biochemical parameters, coagulation test findings, blood gas composition and acid-base state, ECG and X-ray findings.Results. By the 7th day after patient's admission in the ICU, stabilization of hemodynamics, recovery of spontaneous breathing and consciousness, reduction of swelling and the beginning of the formation of pressure ulcers were observed; on the 8 the day, restoration of urination and characteristics of urine were registered. On the 12th day, the patient was transferred to the toxicology unit being in a state of moderate severity and demonstrating positive changes in all clinical parameters.Conclusion. The inclusion of a drug with antioxidant/antihypoxant properties in the infusion therapy scheme allows to relieve metabolic disorders associated with hypoxia, and thereby increase the effectiveness of treatment: i.e. to relief clinical and laboratory manifestations and reduce the ICU stay. |
| first_indexed | 2024-04-10T01:27:38Z |
| format | Article |
| id | doaj.art-d018c139161a4e2a9eaa486d75cbbe73 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2025-03-14T09:45:18Z |
| publishDate | 2018-10-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-d018c139161a4e2a9eaa486d75cbbe732025-03-02T11:29:36ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102018-10-01145253110.15360/1813-9779-2018-5-25-311654Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case)G. A. Livanov0A. N. Lodyagin1A. А. Razina2S. I. Glushkov3A. A. Ivanova4E. V. Volchkova5B. V. Batotsyrenov6I. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of RussiaI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicinePurpose: to contribute to relief of metabolic disorders associated with hypoxia by including a succinate correcting tissue metabolism into the scheme of intensive care of acute severe methadone poisoning complicated by the crush syndrome.Materials and methods. We examined the dynamics of clinical manifestation of acute methadone poisoning complicated by crush syndrome: changes in clinical and biochemical parameters, coagulation test findings, blood gas composition and acid-base state, ECG and X-ray findings.Results. By the 7th day after patient's admission in the ICU, stabilization of hemodynamics, recovery of spontaneous breathing and consciousness, reduction of swelling and the beginning of the formation of pressure ulcers were observed; on the 8 the day, restoration of urination and characteristics of urine were registered. On the 12th day, the patient was transferred to the toxicology unit being in a state of moderate severity and demonstrating positive changes in all clinical parameters.Conclusion. The inclusion of a drug with antioxidant/antihypoxant properties in the infusion therapy scheme allows to relieve metabolic disorders associated with hypoxia, and thereby increase the effectiveness of treatment: i.e. to relief clinical and laboratory manifestations and reduce the ICU stay.https://www.reanimatology.com/rmt/article/view/1710acute poisoningmethadonecrush syndromesuccinic acidreamberin |
| spellingShingle | G. A. Livanov A. N. Lodyagin A. А. Razina S. I. Glushkov A. A. Ivanova E. V. Volchkova B. V. Batotsyrenov Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) Общая реаниматология acute poisoning methadone crush syndrome succinic acid reamberin |
| title | Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) |
| title_full | Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) |
| title_fullStr | Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) |
| title_full_unstemmed | Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) |
| title_short | Favorable Outcome of Severe Acute Methadone Poisoning (Clinical Case) |
| title_sort | favorable outcome of severe acute methadone poisoning clinical case |
| topic | acute poisoning methadone crush syndrome succinic acid reamberin |
| url | https://www.reanimatology.com/rmt/article/view/1710 |
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