Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study
Cross-protection from previous live attenuated vaccines is proposed to explain the low impact of COVID-19 on children. This study aimed to evaluate the effect of live attenuated MMR vaccines on the risk of being hospitalized for COVID-19 in children. An exposed (MMR vaccine)–non-exposed cohort study...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/11/1938 |
| _version_ | 1827643602558255104 |
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| author | Epiphane Kolla Alain Weill David Desplas Laura Semenzato Mahmoud Zureik Lamiae Grimaldi |
| author_facet | Epiphane Kolla Alain Weill David Desplas Laura Semenzato Mahmoud Zureik Lamiae Grimaldi |
| author_sort | Epiphane Kolla |
| collection | DOAJ |
| description | Cross-protection from previous live attenuated vaccines is proposed to explain the low impact of COVID-19 on children. This study aimed to evaluate the effect of live attenuated MMR vaccines on the risk of being hospitalized for COVID-19 in children. An exposed (MMR vaccine)–non-exposed cohort study was conducted using the nationwide French National Health Data System (SNDS). We included children born between 1 January 2009 and 31 December 2019. Exposure was defined as a claim of at least one dose of MMR vaccine since birth. Hospitalization for COVID-19 was defined using main diagnostic ICD10 codes. Non-conditional logistic regression was used to calculate the adjusted odds ratios (aORs) of the association between MMR exposure and hospitalization for COVID-19, controlling for socio-demographic and socio-economic factors, co-morbidities, and general health. In total, 6,800,542 (median age 6 IQR [3–8] years) children exposed to a MMR vaccine and 384,162 (6 [3–9] years) not exposed were followed up with for 18 months. Among them, 873 exposed to the MMR vaccine and 38 who were not exposed were hospitalized for COVID-19. In a multi-variate analysis, the exposure of children to MMR vaccination was not associated with a decreased risk of COVID-19 hospitalization versus non-exposure (aOR (95%CI) = 1.09 [0.81–1.48]). A stratified analysis by age showed an aOR = 1.03 [0.64–1.66] for children aged 1–4, an aOR = 1.38 [0.82–2.31] for those aged 5–9, and an aOR = 1.11 [0.54–2.29] for those aged 10–12. Our study suggests that the live attenuated MMR vaccine does not protect children against COVID-19 hospitalization. |
| first_indexed | 2024-03-09T17:56:35Z |
| format | Article |
| id | doaj.art-d01b346712f540489c370df6f84610b5 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T17:56:35Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d01b346712f540489c370df6f84610b52023-11-24T10:16:56ZengMDPI AGVaccines2076-393X2022-11-011011193810.3390/vaccines10111938Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort StudyEpiphane Kolla0Alain Weill1David Desplas2Laura Semenzato3Mahmoud Zureik4Lamiae Grimaldi5EPI-PHARE (Scientific Interest Group in Epidemiology of Health Products), French National Agency for the Safety of Medicines and Health Products, French National Health Insurance, CEDEX, 93285 Saint-Denis, FranceEPI-PHARE (Scientific Interest Group in Epidemiology of Health Products), French National Agency for the Safety of Medicines and Health Products, French National Health Insurance, CEDEX, 93285 Saint-Denis, FranceEPI-PHARE (Scientific Interest Group in Epidemiology of Health Products), French National Agency for the Safety of Medicines and Health Products, French National Health Insurance, CEDEX, 93285 Saint-Denis, FranceEPI-PHARE (Scientific Interest Group in Epidemiology of Health Products), French National Agency for the Safety of Medicines and Health Products, French National Health Insurance, CEDEX, 93285 Saint-Denis, FranceEPI-PHARE (Scientific Interest Group in Epidemiology of Health Products), French National Agency for the Safety of Medicines and Health Products, French National Health Insurance, CEDEX, 93285 Saint-Denis, FranceClinical Research Unit AP-HP, Paris-Saclay, Hôpital Raymond Poincare, School of Medicine Simone Veil, University Versailles Saint Quentin—University Paris Saclay, INSERM (National Institute of Health and Medical Research), CESP, Anti-Infective Evasion and Pharmacoepidemiology Team, 78180 Montigny-Le-Bretonneux, FranceCross-protection from previous live attenuated vaccines is proposed to explain the low impact of COVID-19 on children. This study aimed to evaluate the effect of live attenuated MMR vaccines on the risk of being hospitalized for COVID-19 in children. An exposed (MMR vaccine)–non-exposed cohort study was conducted using the nationwide French National Health Data System (SNDS). We included children born between 1 January 2009 and 31 December 2019. Exposure was defined as a claim of at least one dose of MMR vaccine since birth. Hospitalization for COVID-19 was defined using main diagnostic ICD10 codes. Non-conditional logistic regression was used to calculate the adjusted odds ratios (aORs) of the association between MMR exposure and hospitalization for COVID-19, controlling for socio-demographic and socio-economic factors, co-morbidities, and general health. In total, 6,800,542 (median age 6 IQR [3–8] years) children exposed to a MMR vaccine and 384,162 (6 [3–9] years) not exposed were followed up with for 18 months. Among them, 873 exposed to the MMR vaccine and 38 who were not exposed were hospitalized for COVID-19. In a multi-variate analysis, the exposure of children to MMR vaccination was not associated with a decreased risk of COVID-19 hospitalization versus non-exposure (aOR (95%CI) = 1.09 [0.81–1.48]). A stratified analysis by age showed an aOR = 1.03 [0.64–1.66] for children aged 1–4, an aOR = 1.38 [0.82–2.31] for those aged 5–9, and an aOR = 1.11 [0.54–2.29] for those aged 10–12. Our study suggests that the live attenuated MMR vaccine does not protect children against COVID-19 hospitalization.https://www.mdpi.com/2076-393X/10/11/1938MMR vaccineSNDSvaccinationCOVID-19hospitalizations |
| spellingShingle | Epiphane Kolla Alain Weill David Desplas Laura Semenzato Mahmoud Zureik Lamiae Grimaldi Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study Vaccines MMR vaccine SNDS vaccination COVID-19 hospitalizations |
| title | Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study |
| title_full | Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study |
| title_fullStr | Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study |
| title_full_unstemmed | Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study |
| title_short | Does Measles, Mumps, and Rubella (MMR) Vaccination Protect against COVID-19 Outcomes: A Nationwide Cohort Study |
| title_sort | does measles mumps and rubella mmr vaccination protect against covid 19 outcomes a nationwide cohort study |
| topic | MMR vaccine SNDS vaccination COVID-19 hospitalizations |
| url | https://www.mdpi.com/2076-393X/10/11/1938 |
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