Data demonstrating the anti-oxidant role of hemopexin in the heart
The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S. Wagner, K. Kreitmeier, L. Silengo, F. Altruda, L...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917302172 |
| _version_ | 1818193139927613440 |
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| author | Giada Ingoglia Can Martin Sag Nikolai Rex Lucia De Franceschi Francesca Vinchi James Cimino Sara Petrillo Stefan Wagner Klaus Kreitmeier Lorenzo Silengo Fiorella Altruda Lars S. Maier Emilio Hirsch Alessandra Ghigo Emanuela Tolosano |
| author_facet | Giada Ingoglia Can Martin Sag Nikolai Rex Lucia De Franceschi Francesca Vinchi James Cimino Sara Petrillo Stefan Wagner Klaus Kreitmeier Lorenzo Silengo Fiorella Altruda Lars S. Maier Emilio Hirsch Alessandra Ghigo Emanuela Tolosano |
| author_sort | Giada Ingoglia |
| collection | DOAJ |
| description | The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S. Wagner, K. Kreitmeier, L. Silengo, F. Altruda, L. S. Maier, E. Hirsch, A. Ghigo and E. Tolosano, 2017) [1]. Data show that heme induces reactive oxygen species (ROS) production in primary cardiomyocytes. H9c2 myoblastic cells treated with heme bound to human Hemopexin (Hx) are protected from heme accumulation and oxidative stress. Similarly, the heme-driven oxidative response is reduced in primary cardiomyocytes treated with Hx-heme compared to heme alone. Our in vivo data show that mouse models of hemolytic disorders, β-thalassemic mice and phenylhydrazine-treated mice, have low serum Hx associated to enhanced expression of heme- and oxidative stress responsive genes in the heart. Hx-/- mice do not show signs of heart fibrosis or overt inflammation. For interpretation and discussion of these data, refer to the research article referenced above. Keywords: Heme, Hemopexin, Heart, Oxidative stress |
| first_indexed | 2024-12-12T00:41:39Z |
| format | Article |
| id | doaj.art-d01bbc229583449697a09dc1ec64aec6 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-12T00:41:39Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-d01bbc229583449697a09dc1ec64aec62022-12-22T00:44:14ZengElsevierData in Brief2352-34092017-08-01136976Data demonstrating the anti-oxidant role of hemopexin in the heartGiada Ingoglia0Can Martin Sag1Nikolai Rex2Lucia De Franceschi3Francesca Vinchi4James Cimino5Sara Petrillo6Stefan Wagner7Klaus Kreitmeier8Lorenzo Silengo9Fiorella Altruda10Lars S. Maier11Emilio Hirsch12Alessandra Ghigo13Emanuela Tolosano14Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyDept. Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyDept. Medicine, Università degli Studi di Verona–Azienda Ospedaliera Universitaria Integrata Verona, Verona, ItalyHeidelberg University Hospital / EMBL Heidelberg, Heidelberg, GermanyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyDept. Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Internal Medicine II, University Hospital Regensburg, Regensburg, GermanyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, ItalyDept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Corresponding author.The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S. Wagner, K. Kreitmeier, L. Silengo, F. Altruda, L. S. Maier, E. Hirsch, A. Ghigo and E. Tolosano, 2017) [1]. Data show that heme induces reactive oxygen species (ROS) production in primary cardiomyocytes. H9c2 myoblastic cells treated with heme bound to human Hemopexin (Hx) are protected from heme accumulation and oxidative stress. Similarly, the heme-driven oxidative response is reduced in primary cardiomyocytes treated with Hx-heme compared to heme alone. Our in vivo data show that mouse models of hemolytic disorders, β-thalassemic mice and phenylhydrazine-treated mice, have low serum Hx associated to enhanced expression of heme- and oxidative stress responsive genes in the heart. Hx-/- mice do not show signs of heart fibrosis or overt inflammation. For interpretation and discussion of these data, refer to the research article referenced above. Keywords: Heme, Hemopexin, Heart, Oxidative stresshttp://www.sciencedirect.com/science/article/pii/S2352340917302172 |
| spellingShingle | Giada Ingoglia Can Martin Sag Nikolai Rex Lucia De Franceschi Francesca Vinchi James Cimino Sara Petrillo Stefan Wagner Klaus Kreitmeier Lorenzo Silengo Fiorella Altruda Lars S. Maier Emilio Hirsch Alessandra Ghigo Emanuela Tolosano Data demonstrating the anti-oxidant role of hemopexin in the heart Data in Brief |
| title | Data demonstrating the anti-oxidant role of hemopexin in the heart |
| title_full | Data demonstrating the anti-oxidant role of hemopexin in the heart |
| title_fullStr | Data demonstrating the anti-oxidant role of hemopexin in the heart |
| title_full_unstemmed | Data demonstrating the anti-oxidant role of hemopexin in the heart |
| title_short | Data demonstrating the anti-oxidant role of hemopexin in the heart |
| title_sort | data demonstrating the anti oxidant role of hemopexin in the heart |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917302172 |
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