Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists

Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists

Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect on the central nervous system. One of the most severe and life-threatening presentations of this syndrom...

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Bibliographic Details
Main Authors: Ana Paula Abdala, Adrian eNewman-Tancredi, John M Bissonnette
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Physiology
Subjects:
Anxiety
Motor Activity
Rett Syndrome
Serotonin
brainstem
breathing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00205/full

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