Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon
Abstract Background Coronary artery spasm (CAS) is an underdiagnosed disease especially in heart transplant patients, and in those patients the etiology and pathophysiology remain largely unknown, although it has been associated with cardiac allograft vasculopathy or graft rejection. Case presentati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-019-01280-8 |
| _version_ | 1818602725316755456 |
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| author | M. Pagnoni J. Regamey J. Adjedj G. Rogati O. Muller P. Tozzi |
| author_facet | M. Pagnoni J. Regamey J. Adjedj G. Rogati O. Muller P. Tozzi |
| author_sort | M. Pagnoni |
| collection | DOAJ |
| description | Abstract Background Coronary artery spasm (CAS) is an underdiagnosed disease especially in heart transplant patients, and in those patients the etiology and pathophysiology remain largely unknown, although it has been associated with cardiac allograft vasculopathy or graft rejection. Case presentation We report the case of a heart-transplant patient whose cardiac graft experienced two coronary vasospasms: the first before transplantation, and the other at one-month of a postoperative course complicated by primary graft failure. Conclusion Our case illustrates that a transplanted heart predisposed with coronary vasospasm may suffer from early relapse in the recipient despite of complete post-surgical autonomic denervation. Exacerbated endothelial dysfunction of the donor heart after transplant, with the addition of systemic factors in the recipient may be involved in the genesis of this puzzling phenomenon. |
| first_indexed | 2024-12-16T13:11:50Z |
| format | Article |
| id | doaj.art-d01d08ef026a4880b1d0053989a26d81 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-16T13:11:50Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-d01d08ef026a4880b1d0053989a26d812022-12-21T22:30:36ZengBMCBMC Cardiovascular Disorders1471-22612019-12-011911610.1186/s12872-019-01280-8Case report - coronary vasospasm in transplanted heart: a puzzling phenomenonM. Pagnoni0J. Regamey1J. Adjedj2G. Rogati3O. Muller4P. Tozzi5Service de chirurgie cardiaque, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisService de cardiologie, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisService de cardiologie, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisTransplant coordination unit, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisService de cardiologie, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisService de chirurgie cardiaque, Département cœur-vaisseaux, Centre Hospitalier Universitaire VaudoisAbstract Background Coronary artery spasm (CAS) is an underdiagnosed disease especially in heart transplant patients, and in those patients the etiology and pathophysiology remain largely unknown, although it has been associated with cardiac allograft vasculopathy or graft rejection. Case presentation We report the case of a heart-transplant patient whose cardiac graft experienced two coronary vasospasms: the first before transplantation, and the other at one-month of a postoperative course complicated by primary graft failure. Conclusion Our case illustrates that a transplanted heart predisposed with coronary vasospasm may suffer from early relapse in the recipient despite of complete post-surgical autonomic denervation. Exacerbated endothelial dysfunction of the donor heart after transplant, with the addition of systemic factors in the recipient may be involved in the genesis of this puzzling phenomenon.https://doi.org/10.1186/s12872-019-01280-8Coronary artery spasmHeart transplantVentricular tachycardiaMyocardial ischemiaCardiac allograft vasculopathyEndothelial dysfunction |
| spellingShingle | M. Pagnoni J. Regamey J. Adjedj G. Rogati O. Muller P. Tozzi Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon BMC Cardiovascular Disorders Coronary artery spasm Heart transplant Ventricular tachycardia Myocardial ischemia Cardiac allograft vasculopathy Endothelial dysfunction |
| title | Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon |
| title_full | Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon |
| title_fullStr | Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon |
| title_full_unstemmed | Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon |
| title_short | Case report - coronary vasospasm in transplanted heart: a puzzling phenomenon |
| title_sort | case report coronary vasospasm in transplanted heart a puzzling phenomenon |
| topic | Coronary artery spasm Heart transplant Ventricular tachycardia Myocardial ischemia Cardiac allograft vasculopathy Endothelial dysfunction |
| url | https://doi.org/10.1186/s12872-019-01280-8 |
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