Interaction of aspirin (acetylsalicylic acid) with lipid membranes.
We studied the interaction of Aspirin (acetylsalicylic acid) with lipid membranes using x-ray diffraction for bilayers containing up to 50 mol% of aspirin. From 2D x-ray intensity maps that cover large areas of reciprocal space we determined the position of the ASA molecules in the phospholipid bila...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3328472?pdf=render |
| _version_ | 1819022104494866432 |
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| author | Matthew A Barrett Songbo Zheng Golnaz Roshankar Richard J Alsop Randy K R Belanger Chris Huynh Norbert Kučerka Maikel C Rheinstädter |
| author_facet | Matthew A Barrett Songbo Zheng Golnaz Roshankar Richard J Alsop Randy K R Belanger Chris Huynh Norbert Kučerka Maikel C Rheinstädter |
| author_sort | Matthew A Barrett |
| collection | DOAJ |
| description | We studied the interaction of Aspirin (acetylsalicylic acid) with lipid membranes using x-ray diffraction for bilayers containing up to 50 mol% of aspirin. From 2D x-ray intensity maps that cover large areas of reciprocal space we determined the position of the ASA molecules in the phospholipid bilayers and the molecular arrangement of the molecules in the plane of the membranes. We present direct experimental evidence that ASA molecules participate in saturated lipid bilayers of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) and preferably reside in the head group region of the membrane. Up to 50 mol% ASA molecules can be dissolved in this type of bilayer before the lateral membrane organization is disturbed and the membranes are found to form an ordered, 2D crystal-like structure. Furthermore, ASA and cholesterol were found to co-exist in saturated lipid bilayers, with the ASA molecules residing in the head group region and the cholesterol molecules participating in the hydrophobic membrane core. |
| first_indexed | 2024-12-21T04:17:42Z |
| format | Article |
| id | doaj.art-d01dee1dcc0e442a9595ba51aa0221cf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:17:42Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d01dee1dcc0e442a9595ba51aa0221cf2022-12-21T19:16:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3435710.1371/journal.pone.0034357Interaction of aspirin (acetylsalicylic acid) with lipid membranes.Matthew A BarrettSongbo ZhengGolnaz RoshankarRichard J AlsopRandy K R BelangerChris HuynhNorbert KučerkaMaikel C RheinstädterWe studied the interaction of Aspirin (acetylsalicylic acid) with lipid membranes using x-ray diffraction for bilayers containing up to 50 mol% of aspirin. From 2D x-ray intensity maps that cover large areas of reciprocal space we determined the position of the ASA molecules in the phospholipid bilayers and the molecular arrangement of the molecules in the plane of the membranes. We present direct experimental evidence that ASA molecules participate in saturated lipid bilayers of DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) and preferably reside in the head group region of the membrane. Up to 50 mol% ASA molecules can be dissolved in this type of bilayer before the lateral membrane organization is disturbed and the membranes are found to form an ordered, 2D crystal-like structure. Furthermore, ASA and cholesterol were found to co-exist in saturated lipid bilayers, with the ASA molecules residing in the head group region and the cholesterol molecules participating in the hydrophobic membrane core.http://europepmc.org/articles/PMC3328472?pdf=render |
| spellingShingle | Matthew A Barrett Songbo Zheng Golnaz Roshankar Richard J Alsop Randy K R Belanger Chris Huynh Norbert Kučerka Maikel C Rheinstädter Interaction of aspirin (acetylsalicylic acid) with lipid membranes. PLoS ONE |
| title | Interaction of aspirin (acetylsalicylic acid) with lipid membranes. |
| title_full | Interaction of aspirin (acetylsalicylic acid) with lipid membranes. |
| title_fullStr | Interaction of aspirin (acetylsalicylic acid) with lipid membranes. |
| title_full_unstemmed | Interaction of aspirin (acetylsalicylic acid) with lipid membranes. |
| title_short | Interaction of aspirin (acetylsalicylic acid) with lipid membranes. |
| title_sort | interaction of aspirin acetylsalicylic acid with lipid membranes |
| url | http://europepmc.org/articles/PMC3328472?pdf=render |
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