Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis
Probiotics have been shown to have a beneficial effect on allergic diseases. Anti-allergic effect of Lacticaseibacillus paracasei was demonstrated in asthma, however, its effect in combined allergic rhinitis and asthma syndrome (CARAS) is still unclear. This study evaluated the Lacticaseibacillus pa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624001117 |
| _version_ | 1827313756754935808 |
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| author | Raquel F.P. Cavalcanti Francisco A.A.F. Gadelha Laercia K.D. Paiva Ferreira Larissa A.M. Paiva Ferreira José Venâncio C. Júnior Rayanne S. de Araújo Batista Taynara B. Lins Fábio S. de Souza Adriano F. Alves Leônia Maria Batista Naiara N. Dejani Marcia R. Piuvezam |
| author_facet | Raquel F.P. Cavalcanti Francisco A.A.F. Gadelha Laercia K.D. Paiva Ferreira Larissa A.M. Paiva Ferreira José Venâncio C. Júnior Rayanne S. de Araújo Batista Taynara B. Lins Fábio S. de Souza Adriano F. Alves Leônia Maria Batista Naiara N. Dejani Marcia R. Piuvezam |
| author_sort | Raquel F.P. Cavalcanti |
| collection | DOAJ |
| description | Probiotics have been shown to have a beneficial effect on allergic diseases. Anti-allergic effect of Lacticaseibacillus paracasei was demonstrated in asthma, however, its effect in combined allergic rhinitis and asthma syndrome (CARAS) is still unclear. This study evaluated the Lacticaseibacillus paracasei (LPc-G110) supplementation in CARAS mice model. BALB/c mice were ovalbumin-sensitized and challenged after being supplemented with LPc-G110. Supplemented animals showed reduced allergic rhinitis signs, eosinophilic infiltration, mucus, extracellular matrix deposition into airway tissues, and lung smooth muscle hypertrophy. LPc-G110 supplementation also reduced eosinophilia, serum levels of allergen-specific IgE, IL-4, IL-13, and IL-5, and favored the production of IFN-γ, IL-10, and short-chain fatty acids. Additionally, LPc-G110 supplementation preserved the gut tissue integrity and epithelial barrier by increasing the tight junction protein ZO-1. Therefore, LPc-G110 improves the gut-airway axis in CARAS by ameliorating inflammatory parameters in both compartments and is a promising candidate for preventing allergic airway diseases. |
| first_indexed | 2024-04-24T22:21:50Z |
| format | Article |
| id | doaj.art-d01fcb360a074f3d8c7aec5af34ed0d3 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-24T22:21:50Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-d01fcb360a074f3d8c7aec5af34ed0d32024-03-20T06:09:06ZengElsevierJournal of Functional Foods1756-46462024-04-01115106109Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axisRaquel F.P. Cavalcanti0Francisco A.A.F. Gadelha1Laercia K.D. Paiva Ferreira2Larissa A.M. Paiva Ferreira3José Venâncio C. Júnior4Rayanne S. de Araújo Batista5Taynara B. Lins6Fábio S. de Souza7Adriano F. Alves8Leônia Maria Batista9Naiara N. Dejani10Marcia R. Piuvezam11Laboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilLaboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Medicina, Universidade Federal de Alagoas, Arapiraca, AL, BrazilLaboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil; Programa de Pós-grauação em Desenvolvimento e Inovação em Medicamentos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilLaboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil; Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa, PB, BrazilDepartamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil; Laboratório de Farmacologia do Trato Gastrointestinal, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilDepartamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa, PB, Brazil; Laboratório de Imunofarmacologia, Programa de Pós-graduação em Ciências da Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, BrazilLaboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil; Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa, PB, Brazil; Corresponding author at: Laboratory of Immunopharmacology, João Pessoa, PB, Brazil.Probiotics have been shown to have a beneficial effect on allergic diseases. Anti-allergic effect of Lacticaseibacillus paracasei was demonstrated in asthma, however, its effect in combined allergic rhinitis and asthma syndrome (CARAS) is still unclear. This study evaluated the Lacticaseibacillus paracasei (LPc-G110) supplementation in CARAS mice model. BALB/c mice were ovalbumin-sensitized and challenged after being supplemented with LPc-G110. Supplemented animals showed reduced allergic rhinitis signs, eosinophilic infiltration, mucus, extracellular matrix deposition into airway tissues, and lung smooth muscle hypertrophy. LPc-G110 supplementation also reduced eosinophilia, serum levels of allergen-specific IgE, IL-4, IL-13, and IL-5, and favored the production of IFN-γ, IL-10, and short-chain fatty acids. Additionally, LPc-G110 supplementation preserved the gut tissue integrity and epithelial barrier by increasing the tight junction protein ZO-1. Therefore, LPc-G110 improves the gut-airway axis in CARAS by ameliorating inflammatory parameters in both compartments and is a promising candidate for preventing allergic airway diseases.http://www.sciencedirect.com/science/article/pii/S1756464624001117Lacticaseibacillus paracasei (LPc-G110)SCFAsGut airway axisAllergyCARAS |
| spellingShingle | Raquel F.P. Cavalcanti Francisco A.A.F. Gadelha Laercia K.D. Paiva Ferreira Larissa A.M. Paiva Ferreira José Venâncio C. Júnior Rayanne S. de Araújo Batista Taynara B. Lins Fábio S. de Souza Adriano F. Alves Leônia Maria Batista Naiara N. Dejani Marcia R. Piuvezam Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis Journal of Functional Foods Lacticaseibacillus paracasei (LPc-G110) SCFAs Gut airway axis Allergy CARAS |
| title | Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis |
| title_full | Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis |
| title_fullStr | Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis |
| title_full_unstemmed | Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis |
| title_short | Oral administration of Lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome (CARAS) in mice model: Relevance of short-chain fatty acids on gut-airway axis |
| title_sort | oral administration of lacticaseibacillus paracasei attenuates combined allergic rhinitis and asthma syndrome caras in mice model relevance of short chain fatty acids on gut airway axis |
| topic | Lacticaseibacillus paracasei (LPc-G110) SCFAs Gut airway axis Allergy CARAS |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624001117 |
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