ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi

ATP and NADPH engineering of Escherichia coli to improve the production of 4-hydroxyphenylacetic acid using CRISPRi

Abstract Background 4-Hydroxyphenylacetic acid (4HPAA) is an important raw material for the synthesis of drugs, pesticides and biochemicals. Microbial biotechnology would be an attractive approach for 4HPAA production, and cofactors play an important role in biosynthesis. Results We developed a nove...

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Bibliographic Details
Main Authors:	Yu-Ping Shen, Yu-Ling Liao, Qian Lu, Xin He, Zhi-Bo Yan, Jian-Zhong Liu
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Series:	Biotechnology for Biofuels
Subjects:	4-Hydroxyphenylacetic acid ATP engineering NADPH engineering CRISPRi Escherichia coli
Online Access:	https://doi.org/10.1186/s13068-021-01954-6

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