Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

Abstract In atherosclerotic lesions, blood-derived monocytes differentiate into distinct macrophage subpopulations, and further into cholesterol-filled foam cells under a complex milieu of cytokines, which also contains macrophage-colony stimulating factor (M-CSF) and granulocyte–macrophage-colony s...

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Bibliographic Details
Main Authors:	Jani Lappalainen, Nicolas Yeung, Su D. Nguyen, Matti Jauhiainen, Petri T. Kovanen, Miriam Lee-Rueckert
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-84249-y

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