Periodontal ligament stem cells as a promising therapeutic target for neural damage
Abstract Background The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applications that can improve the injured microenvironment of the damaged neura...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02942-9 |
| _version_ | 1811334652921643008 |
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| author | Fariba Mohebichamkhorami Roya Fattahi Zahra Niknam Morteza Aliashrafi Sahar Khakpour Naeimi Samira Gilanchi Hakimeh Zali |
| author_facet | Fariba Mohebichamkhorami Roya Fattahi Zahra Niknam Morteza Aliashrafi Sahar Khakpour Naeimi Samira Gilanchi Hakimeh Zali |
| author_sort | Fariba Mohebichamkhorami |
| collection | DOAJ |
| description | Abstract Background The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applications that can improve the injured microenvironment of the damaged neural system. They provide neuronal progenitors and neurotrophic, anti-apoptotic and anti-inflammatory factors. In this study, we aimed to comprehensively explore the various neuronal differentiation potentials of PDLSCs for application in neural regeneration therapy. Main text PDLSCs have superior potential to differentiate into various neural-like cells through a dedifferentiation stage followed by differentiation process without need for cell division. Diverse combination of nutritional factors can be used to induce the PDLSCs toward neural lineage. PDLSCs when coupled with biomaterials could have significant implications for neural tissue repair. PDLSCs can be a new clinical research target for Alzheimer's disease treatment, multiple sclerosis and cerebral ischemia. Moreover, PDLSCs have beneficial effects on retinal ganglion cell regeneration and photoreceptor survival. PDLSCs can be a great source for the repair of injured peripheral nerve through the expression of several neural growth factors and differentiation into Schwann cells. Conclusion In conclusion, these cells are an appealing source for utilizing in clinical treatment of the neuropathological disorders. Although significant in vitro and in vivo investigations were carried out in order for neural differentiation evaluation of these cells into diverse types of neurons, more preclinical and clinical studies are needed to elucidate their therapeutic potential for neural diseases. |
| first_indexed | 2024-04-13T17:12:15Z |
| format | Article |
| id | doaj.art-d024fdb100ea4d15b3ebce908ba393e3 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-13T17:12:15Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-d024fdb100ea4d15b3ebce908ba393e32022-12-22T02:38:15ZengBMCStem Cell Research & Therapy1757-65122022-06-0113111410.1186/s13287-022-02942-9Periodontal ligament stem cells as a promising therapeutic target for neural damageFariba Mohebichamkhorami0Roya Fattahi1Zahra Niknam2Morteza Aliashrafi3Sahar Khakpour Naeimi4Samira Gilanchi5Hakimeh Zali6Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesFaculty of Paramedical Sciences, Shahid Beheshti University of Medical SciencesDepartment of Cognitive Neuroscience, Institute for Cognitive Science StudiesDepartment of Biology, Tehran Central Branch, Islamic Azad UniversityFaculty of Paramedical Sciences, Shahid Beheshti University of Medical SciencesDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesAbstract Background The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem cells (PDLSCs) are the promising source for neuroregenerative applications that can improve the injured microenvironment of the damaged neural system. They provide neuronal progenitors and neurotrophic, anti-apoptotic and anti-inflammatory factors. In this study, we aimed to comprehensively explore the various neuronal differentiation potentials of PDLSCs for application in neural regeneration therapy. Main text PDLSCs have superior potential to differentiate into various neural-like cells through a dedifferentiation stage followed by differentiation process without need for cell division. Diverse combination of nutritional factors can be used to induce the PDLSCs toward neural lineage. PDLSCs when coupled with biomaterials could have significant implications for neural tissue repair. PDLSCs can be a new clinical research target for Alzheimer's disease treatment, multiple sclerosis and cerebral ischemia. Moreover, PDLSCs have beneficial effects on retinal ganglion cell regeneration and photoreceptor survival. PDLSCs can be a great source for the repair of injured peripheral nerve through the expression of several neural growth factors and differentiation into Schwann cells. Conclusion In conclusion, these cells are an appealing source for utilizing in clinical treatment of the neuropathological disorders. Although significant in vitro and in vivo investigations were carried out in order for neural differentiation evaluation of these cells into diverse types of neurons, more preclinical and clinical studies are needed to elucidate their therapeutic potential for neural diseases.https://doi.org/10.1186/s13287-022-02942-9Periodontal ligament stem cellsNeural regenerationNeural differentiationNeurotrophic factorsApoptosisInflammation |
| spellingShingle | Fariba Mohebichamkhorami Roya Fattahi Zahra Niknam Morteza Aliashrafi Sahar Khakpour Naeimi Samira Gilanchi Hakimeh Zali Periodontal ligament stem cells as a promising therapeutic target for neural damage Stem Cell Research & Therapy Periodontal ligament stem cells Neural regeneration Neural differentiation Neurotrophic factors Apoptosis Inflammation |
| title | Periodontal ligament stem cells as a promising therapeutic target for neural damage |
| title_full | Periodontal ligament stem cells as a promising therapeutic target for neural damage |
| title_fullStr | Periodontal ligament stem cells as a promising therapeutic target for neural damage |
| title_full_unstemmed | Periodontal ligament stem cells as a promising therapeutic target for neural damage |
| title_short | Periodontal ligament stem cells as a promising therapeutic target for neural damage |
| title_sort | periodontal ligament stem cells as a promising therapeutic target for neural damage |
| topic | Periodontal ligament stem cells Neural regeneration Neural differentiation Neurotrophic factors Apoptosis Inflammation |
| url | https://doi.org/10.1186/s13287-022-02942-9 |
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