Pleomorphic xanthoastrocytoma with anaplastic features: A case report
Pleomorphic xanthoastrocytoma has been considered as an astrocytic tumor with relatively favorable prognosis. It corresponds to WHO Grade-II neoplasm. Recently, several patterns with relatively poor prognosis have been recorded and a new concept of "PXA with anaplastic features" has been p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=101;epage=104;aulast=Niamathullah |
| _version_ | 1818162243229974528 |
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| author | Sadiya Niamathullah S Sivaselvam Mitra Ghosh Siddhartha Ghosh |
| author_facet | Sadiya Niamathullah S Sivaselvam Mitra Ghosh Siddhartha Ghosh |
| author_sort | Sadiya Niamathullah |
| collection | DOAJ |
| description | Pleomorphic xanthoastrocytoma has been considered as an astrocytic tumor with relatively favorable prognosis. It corresponds to WHO Grade-II neoplasm. Recently, several patterns with relatively poor prognosis have been recorded and a new concept of "PXA with anaplastic features" has been proposed. The present case is about a 9-year-old girl who presented with symptoms of recurrent headache, seizures and poor academic performance. MRI revealed left fronto-parietal irregular enhancing mass lesion with callosal involvement and right mid-brain arteriovenous malformation. Clinical and radiological examination was suggestive of a high grade glial neoplasm/PNET. A diagnosis of high grade glial neoplasm was rendered on the squash smears submitted for frozen sections based on the presence of spindle cells, admixed with pleomorphic bizarre, giant cells with multilobated nuclei showing few atypical mitosis and abundant eosinophilic cytoplasm. Frontal craniotomy with debulking of the tumor was performed and permanent sections revealed a biphasic glial neoplasm with spindle cells arranged in fascicles admixed with bizarre multinucleated giant cells showing abundant vacuolated and lipidized cytoplasm, nuclear hyperchromasia with intranuclear inclusions. Eosinophilic granular bodies, mitosis of 7/10 HPF, micro vascular proliferation, necrosis and invasion into the underlying brain parenchyma were noted. With these histomorphological findings a diagnosis of pleomorphic xanthoastrocytoma with anaplastic features was rendered. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-11T16:30:34Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-d0250c65c075478783188a67e23751cc2022-12-22T00:58:36ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292014-01-0157110110410.4103/0377-4929.130913Pleomorphic xanthoastrocytoma with anaplastic features: A case reportSadiya NiamathullahS SivaselvamMitra GhoshSiddhartha GhoshPleomorphic xanthoastrocytoma has been considered as an astrocytic tumor with relatively favorable prognosis. It corresponds to WHO Grade-II neoplasm. Recently, several patterns with relatively poor prognosis have been recorded and a new concept of "PXA with anaplastic features" has been proposed. The present case is about a 9-year-old girl who presented with symptoms of recurrent headache, seizures and poor academic performance. MRI revealed left fronto-parietal irregular enhancing mass lesion with callosal involvement and right mid-brain arteriovenous malformation. Clinical and radiological examination was suggestive of a high grade glial neoplasm/PNET. A diagnosis of high grade glial neoplasm was rendered on the squash smears submitted for frozen sections based on the presence of spindle cells, admixed with pleomorphic bizarre, giant cells with multilobated nuclei showing few atypical mitosis and abundant eosinophilic cytoplasm. Frontal craniotomy with debulking of the tumor was performed and permanent sections revealed a biphasic glial neoplasm with spindle cells arranged in fascicles admixed with bizarre multinucleated giant cells showing abundant vacuolated and lipidized cytoplasm, nuclear hyperchromasia with intranuclear inclusions. Eosinophilic granular bodies, mitosis of 7/10 HPF, micro vascular proliferation, necrosis and invasion into the underlying brain parenchyma were noted. With these histomorphological findings a diagnosis of pleomorphic xanthoastrocytoma with anaplastic features was rendered.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=101;epage=104;aulast=NiamathullahAnaplastic featuresastrocytic tumorpleomorphic xanthoastrocytoma |
| spellingShingle | Sadiya Niamathullah S Sivaselvam Mitra Ghosh Siddhartha Ghosh Pleomorphic xanthoastrocytoma with anaplastic features: A case report Indian Journal of Pathology and Microbiology Anaplastic features astrocytic tumor pleomorphic xanthoastrocytoma |
| title | Pleomorphic xanthoastrocytoma with anaplastic features: A case report |
| title_full | Pleomorphic xanthoastrocytoma with anaplastic features: A case report |
| title_fullStr | Pleomorphic xanthoastrocytoma with anaplastic features: A case report |
| title_full_unstemmed | Pleomorphic xanthoastrocytoma with anaplastic features: A case report |
| title_short | Pleomorphic xanthoastrocytoma with anaplastic features: A case report |
| title_sort | pleomorphic xanthoastrocytoma with anaplastic features a case report |
| topic | Anaplastic features astrocytic tumor pleomorphic xanthoastrocytoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=101;epage=104;aulast=Niamathullah |
| work_keys_str_mv | AT sadiyaniamathullah pleomorphicxanthoastrocytomawithanaplasticfeaturesacasereport AT ssivaselvam pleomorphicxanthoastrocytomawithanaplasticfeaturesacasereport AT mitraghosh pleomorphicxanthoastrocytomawithanaplasticfeaturesacasereport AT siddharthaghosh pleomorphicxanthoastrocytomawithanaplasticfeaturesacasereport |