Persistent Coxsackievirus B3 Infection in Pancreatic Ductal Cells In Vitro Downregulates Cellular Polyamine Metabolism

Persistent Coxsackievirus B3 Infection in Pancreatic Ductal Cells In Vitro Downregulates Cellular Polyamine Metabolism

ABSTRACT Picornaviruses infect a wide variety of cell types in vitro, with rapid replication kinetics and pronounced cytopathic effect. Coxsackievirus B3 (CVB3) can also establish a persistent infection in vivo that can lead to pathology, including dilated cardiomyopathy and myocarditis. One model s...

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Bibliographic Details
Main Authors: Vincent Mastrodomenico, Natalie J. LoMascolo, Mason R. Firpo, Maria del Mar Villanueva Guzman, Adam Zaporowski, Bryan C. Mounce
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mSphere
Subjects:
persistence
coxsackievirus
polyamines
pancreatic ductal cells
enterovirus
Online Access:https://journals.asm.org/doi/10.1128/msphere.00036-23

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