Investigation of fragmentation behaviors of steroidal drugs with Li+, Na+, K+ adducts by tandem mass spectrometry aided with computational analysis

Investigation of fragmentation behaviors of steroidal drugs with Li+, Na+, K+ adducts by tandem mass spectrometry aided with computational analysis

In this study, we have investigated the fragmentation of the widely used steroidal pharmaceutical drugs (n = 14), complexed by a singly charged proton or alkali metal ion (Li+, Na+, K+) using Ion trap and quadrupole time-of-flight mass spectrometers. Spectra were collected by LC-MS/MS analysis using...

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Bibliographic Details
Main Authors: Adeeba Khadim, Syed Usama Yaseen Jeelani, Naheed Akhtar, Arslan Ali, Syed Mohammad Zaki Shah, Bibi Zareena, Syeda Tehreem, Jalal Uddin, Hesham R. El-Seedi, Syed Ghulam Musharraf
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Arabian Journal of Chemistry
Subjects:
Drugs
Metal adducts
Fragmentation
ESI-MS/MS
Computational studies
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222002556

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