Autophagy and its role in osteosarcoma
Abstract Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at develo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5407 |
| _version_ | 1827986495640698880 |
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| author | Biao Ning Yixin Liu Tianhe Huang Yongchang Wei |
| author_facet | Biao Ning Yixin Liu Tianhe Huang Yongchang Wei |
| author_sort | Biao Ning |
| collection | DOAJ |
| description | Abstract Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at developing new therapeutic targets for OS are urgently needed. Autophagy, a conserved process which allows cells to recycle altered or unused organelles and cellular components, has been proven to play a critical role in multiple biological processes in OS. In this article, we summarized the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of OS, revealing that autophagy‐related genes and pathways could serve as potential targets for OS therapy. |
| first_indexed | 2024-04-09T23:32:16Z |
| format | Article |
| id | doaj.art-d02823c8fabd46da838917a2ac7f4a3b |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T23:32:16Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-d02823c8fabd46da838917a2ac7f4a3b2023-03-21T05:20:40ZengWileyCancer Medicine2045-76342023-03-011255676568710.1002/cam4.5407Autophagy and its role in osteosarcomaBiao Ning0Yixin Liu1Tianhe Huang2Yongchang Wei3Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei ChinaDepartment of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei ChinaDepartment of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei ChinaDepartment of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei ChinaAbstract Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at developing new therapeutic targets for OS are urgently needed. Autophagy, a conserved process which allows cells to recycle altered or unused organelles and cellular components, has been proven to play a critical role in multiple biological processes in OS. In this article, we summarized the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of OS, revealing that autophagy‐related genes and pathways could serve as potential targets for OS therapy.https://doi.org/10.1002/cam4.5407autophagychemotherapyosteosarcomaprogressionradiotherapyimmunotherapy |
| spellingShingle | Biao Ning Yixin Liu Tianhe Huang Yongchang Wei Autophagy and its role in osteosarcoma Cancer Medicine autophagy chemotherapy osteosarcoma progression radiotherapy immunotherapy |
| title | Autophagy and its role in osteosarcoma |
| title_full | Autophagy and its role in osteosarcoma |
| title_fullStr | Autophagy and its role in osteosarcoma |
| title_full_unstemmed | Autophagy and its role in osteosarcoma |
| title_short | Autophagy and its role in osteosarcoma |
| title_sort | autophagy and its role in osteosarcoma |
| topic | autophagy chemotherapy osteosarcoma progression radiotherapy immunotherapy |
| url | https://doi.org/10.1002/cam4.5407 |
| work_keys_str_mv | AT biaoning autophagyanditsroleinosteosarcoma AT yixinliu autophagyanditsroleinosteosarcoma AT tianhehuang autophagyanditsroleinosteosarcoma AT yongchangwei autophagyanditsroleinosteosarcoma |