Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants

Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants

Abstract Background Extremely preterm infants have a high mortality and morbidity. Here, we present a statistical analysis plan for secondary Bayesian analyses of the pragmatic, sufficiently powered multinational, trial—SafeBoosC III—evaluating the benefits and harms of cerebral oximetry monitoring...

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Bibliographic Details
Main Authors: Markus Harboe Olsen, Mathias Lühr Hansen, Theis Lange, Christian Gluud, Lehana Thabane, Gorm Greisen, Janus Christian Jakobsen, the SafeBoosC-III Trial Group
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Trials
Subjects:
Randomised clinical trial
Extremely preterm
Cerebral oximetry
Near-infrared spectroscopy
Statistical analysis plan
Bayesian statistics
Online Access:https://doi.org/10.1186/s13063-023-07720-3

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