Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway

Abstract Background Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of alveolar units. This study aims to investigate the potential role and mechanism of fibroblast growth factor 21 (FGF21), a metabolic regulator secret...

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Bibliographic Details
Main Authors: Peng Ding, Rui Yang, Cheng Li, Hai-Long Fu, Guang-Li Ren, Pei Wang, Dong-Yu Zheng, Wei Chen, Li-Ye Yang, Yan-Fei Mao, Hong-Bin Yuan, Yong-Hua Li
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Critical Care
Subjects:
Ventilator-induced lung injury
Fibroblast growth factor 21
Pyroptosis
NLRP3
Caspase-1
Gasdermin D
Online Access:https://doi.org/10.1186/s13054-023-04488-5

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