Characteristics of responders to atropine 0.01% as treatment in Asian myopic children
Abstract Recently, low-concentration atropine (0.01%) has gained increased attention in controlling myopia progression with satisfying effects and minimal side effects. However, studies concerning responders to 0.01% atropine are limited. This retrospective observational cohort study aimed to determ...
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| Format: | Article |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10978-3 |
| _version_ | 1818250692150689792 |
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| author | Lung-Chi Lee Meng-Wei Hsieh Yi-Hao Chen Po-Liang Chen Ke-Hung Chien |
| author_facet | Lung-Chi Lee Meng-Wei Hsieh Yi-Hao Chen Po-Liang Chen Ke-Hung Chien |
| author_sort | Lung-Chi Lee |
| collection | DOAJ |
| description | Abstract Recently, low-concentration atropine (0.01%) has gained increased attention in controlling myopia progression with satisfying effects and minimal side effects. However, studies concerning responders to 0.01% atropine are limited. This retrospective observational cohort study aimed to determine the responder characteristics of 0.01% atropine in Asian children. One hundred forty children (aged between 3 and 15 years) receiving 0.01% atropine were analyzed for the factors influencing annual spherical equivalent changes (SE). The mean age was 9.13 (2.6) years, the mean baseline SE was − 1.56 (1.52) diopters (D), and the mean annual SE change was − 0.52 (0.49) D. A 58.63% responder rate (146/249) of myopic control was achieved with 0.01% atropine in our entire cohort under the criteria of less than 0.5 D of myopic progression annually. The subjects were stratified into 4 subgroups based on a cut-off point of baseline SE of − 1.5 D and baseline age of 9 years. The responder rate differed significantly with the highest being the youngest with the lowest myopia subgroups. Our results demonstrated that children with myopia better than − 1.5 D and younger than 9 years had the highest potential to achieve successful myopic control under 0.01% atropine therapy. |
| first_indexed | 2024-12-12T15:56:25Z |
| format | Article |
| id | doaj.art-d02f54400cc2492597883318865d2559 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T15:56:25Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d02f54400cc2492597883318865d25592022-12-22T00:19:29ZengNature PortfolioScientific Reports2045-23222022-05-011211710.1038/s41598-022-10978-3Characteristics of responders to atropine 0.01% as treatment in Asian myopic childrenLung-Chi Lee0Meng-Wei Hsieh1Yi-Hao Chen2Po-Liang Chen3Ke-Hung Chien4Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical CenterDepartment of Ophthalmology, Taoyuan Armed Forces General HospitalDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical CenterHau-Ming Eye Clinic CenterDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical CenterAbstract Recently, low-concentration atropine (0.01%) has gained increased attention in controlling myopia progression with satisfying effects and minimal side effects. However, studies concerning responders to 0.01% atropine are limited. This retrospective observational cohort study aimed to determine the responder characteristics of 0.01% atropine in Asian children. One hundred forty children (aged between 3 and 15 years) receiving 0.01% atropine were analyzed for the factors influencing annual spherical equivalent changes (SE). The mean age was 9.13 (2.6) years, the mean baseline SE was − 1.56 (1.52) diopters (D), and the mean annual SE change was − 0.52 (0.49) D. A 58.63% responder rate (146/249) of myopic control was achieved with 0.01% atropine in our entire cohort under the criteria of less than 0.5 D of myopic progression annually. The subjects were stratified into 4 subgroups based on a cut-off point of baseline SE of − 1.5 D and baseline age of 9 years. The responder rate differed significantly with the highest being the youngest with the lowest myopia subgroups. Our results demonstrated that children with myopia better than − 1.5 D and younger than 9 years had the highest potential to achieve successful myopic control under 0.01% atropine therapy.https://doi.org/10.1038/s41598-022-10978-3 |
| spellingShingle | Lung-Chi Lee Meng-Wei Hsieh Yi-Hao Chen Po-Liang Chen Ke-Hung Chien Characteristics of responders to atropine 0.01% as treatment in Asian myopic children Scientific Reports |
| title | Characteristics of responders to atropine 0.01% as treatment in Asian myopic children |
| title_full | Characteristics of responders to atropine 0.01% as treatment in Asian myopic children |
| title_fullStr | Characteristics of responders to atropine 0.01% as treatment in Asian myopic children |
| title_full_unstemmed | Characteristics of responders to atropine 0.01% as treatment in Asian myopic children |
| title_short | Characteristics of responders to atropine 0.01% as treatment in Asian myopic children |
| title_sort | characteristics of responders to atropine 0 01 as treatment in asian myopic children |
| url | https://doi.org/10.1038/s41598-022-10978-3 |
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