The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/245 |
| _version_ | 1797625717831237632 |
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| author | Vinicio Carloni Elisa Morganti Andrea Galli Antonio Mazzocca |
| author_facet | Vinicio Carloni Elisa Morganti Andrea Galli Antonio Mazzocca |
| author_sort | Vinicio Carloni |
| collection | DOAJ |
| description | Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors. |
| first_indexed | 2024-03-11T10:00:16Z |
| format | Article |
| id | doaj.art-d030136d44824362943cfc41df2d9839 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T10:00:16Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d030136d44824362943cfc41df2d98392023-11-16T15:30:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124124510.3390/ijms24010245The Adaptability of Chromosomal Instability in Cancer Therapy and ResistanceVinicio Carloni0Elisa Morganti1Andrea Galli2Antonio Mazzocca3Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50121 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50121 Florence, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, 50121 Florence, ItalyInterdisciplinary Department of Medicine, University of Bari-School of Medicine, 70121 Bari, ItalyVariation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors.https://www.mdpi.com/1422-0067/24/1/245DNA damage responseDNA damageepigenetic changesimmunotherapyimmune evasion |
| spellingShingle | Vinicio Carloni Elisa Morganti Andrea Galli Antonio Mazzocca The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance International Journal of Molecular Sciences DNA damage response DNA damage epigenetic changes immunotherapy immune evasion |
| title | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
| title_full | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
| title_fullStr | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
| title_full_unstemmed | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
| title_short | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
| title_sort | adaptability of chromosomal instability in cancer therapy and resistance |
| topic | DNA damage response DNA damage epigenetic changes immunotherapy immune evasion |
| url | https://www.mdpi.com/1422-0067/24/1/245 |
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