The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance

The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance

Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary me...

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Bibliographic Details
Main Authors: Vinicio Carloni, Elisa Morganti, Andrea Galli, Antonio Mazzocca
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage response
DNA damage
epigenetic changes
immunotherapy
immune evasion
Online Access:https://www.mdpi.com/1422-0067/24/1/245

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