Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial
Abstract Rapid hepatitis B (HB) surface antibody (anti-HBs) loss is prevalent after liver transplantation (LT). Herein, we evaluated anti-HBs persistence after HB vaccination using two regimens in LT children. We recruited 66 previously immunized LT children with anti-HBs level of < 100 mIU/mL. P...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51149-w |
| _version_ | 1797363470090371072 |
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| author | Palittiya Sintusek Supranee Buranapraditkun Siriporn Khunsri Warunee Polsawat Preeyaporn Vichaiwattana Yong Poovorawan |
| author_facet | Palittiya Sintusek Supranee Buranapraditkun Siriporn Khunsri Warunee Polsawat Preeyaporn Vichaiwattana Yong Poovorawan |
| author_sort | Palittiya Sintusek |
| collection | DOAJ |
| description | Abstract Rapid hepatitis B (HB) surface antibody (anti-HBs) loss is prevalent after liver transplantation (LT). Herein, we evaluated anti-HBs persistence after HB vaccination using two regimens in LT children. We recruited 66 previously immunized LT children with anti-HBs level of < 100 mIU/mL. Participants were randomly reimmunized with standard-three-dose (SD) and double-three-dose (DD) intramuscular HB vaccination at 0, 1, and 6 months. Anti-HBs were assessed at every outpatient visit. Antibody loss defined as anti-HBs levels < 100 mIU/mL after three-dose vaccination. After three-dose vaccination, 81.8% and 78.7% of participants in the SD and DD groups, had anti-HBs levels > 100 mIU/mL, with a geometric mean titer (GMT) of 601.68 and 668.01 mIU/mL (P = 0.983). After a mean follow-up of 2.31 years, the anti-HBs GMT was 209.81 and 212.61 mIU/mL in the SD and DD groups (P = 0.969). The number of immunosuppressants used and an anti-HBs level < 1 mIU/mL at baseline were independently associated with anti-HB loss. The DD regimen strongly increased the risk of anti-HBs loss (adjusted hazard ratio, 2.97 [1.21–7.31]; P = 0.018). The SD HB reimmunization regimen effectively maintained protective anti-HBs levels in children undergoing LT, making it the preferred regimen for such children with anti-HB loss. Trial registration: TCTR20180723002. |
| first_indexed | 2024-03-08T16:20:49Z |
| format | Article |
| id | doaj.art-d030ebc3867545f6915adf838ef8d477 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:20:49Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d030ebc3867545f6915adf838ef8d4772024-01-07T12:22:42ZengNature PortfolioScientific Reports2045-23222024-01-011411810.1038/s41598-024-51149-wAntibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trialPalittiya Sintusek0Supranee Buranapraditkun1Siriporn Khunsri2Warunee Polsawat3Preeyaporn Vichaiwattana4Yong Poovorawan5Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital and the Thai Red Cross Society, Chulalongkorn UniversityCenter of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital and the Thai Red Cross Society, Chulalongkorn UniversityCenter of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital and the Thai Red Cross Society, Chulalongkorn UniversityExcellence Center for Organ Transplantation, King Chulalongkorn Memorial Hospital and the Thai Red Cross SocietyExcellence Center of Clinical Virology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn UniversityExcellence Center of Clinical Virology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn UniversityAbstract Rapid hepatitis B (HB) surface antibody (anti-HBs) loss is prevalent after liver transplantation (LT). Herein, we evaluated anti-HBs persistence after HB vaccination using two regimens in LT children. We recruited 66 previously immunized LT children with anti-HBs level of < 100 mIU/mL. Participants were randomly reimmunized with standard-three-dose (SD) and double-three-dose (DD) intramuscular HB vaccination at 0, 1, and 6 months. Anti-HBs were assessed at every outpatient visit. Antibody loss defined as anti-HBs levels < 100 mIU/mL after three-dose vaccination. After three-dose vaccination, 81.8% and 78.7% of participants in the SD and DD groups, had anti-HBs levels > 100 mIU/mL, with a geometric mean titer (GMT) of 601.68 and 668.01 mIU/mL (P = 0.983). After a mean follow-up of 2.31 years, the anti-HBs GMT was 209.81 and 212.61 mIU/mL in the SD and DD groups (P = 0.969). The number of immunosuppressants used and an anti-HBs level < 1 mIU/mL at baseline were independently associated with anti-HB loss. The DD regimen strongly increased the risk of anti-HBs loss (adjusted hazard ratio, 2.97 [1.21–7.31]; P = 0.018). The SD HB reimmunization regimen effectively maintained protective anti-HBs levels in children undergoing LT, making it the preferred regimen for such children with anti-HB loss. Trial registration: TCTR20180723002.https://doi.org/10.1038/s41598-024-51149-w |
| spellingShingle | Palittiya Sintusek Supranee Buranapraditkun Siriporn Khunsri Warunee Polsawat Preeyaporn Vichaiwattana Yong Poovorawan Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial Scientific Reports |
| title | Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial |
| title_full | Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial |
| title_fullStr | Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial |
| title_full_unstemmed | Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial |
| title_short | Antibody persistence of standard versus double three-dose hepatitis B vaccine in liver transplant children: a randomized controlled trial |
| title_sort | antibody persistence of standard versus double three dose hepatitis b vaccine in liver transplant children a randomized controlled trial |
| url | https://doi.org/10.1038/s41598-024-51149-w |
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