Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility
Smooth muscle is a central structure involved in the regulation of airway tone. In addition, it plays an important role in the development of some pathologies generated by alterations in contraction, such as hypercontractility and the airway hyperresponsiveness observed in asthma. The molecular proc...
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| Format: | Article |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00701/full |
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| author | Mayra D. Álvarez-Santos Marisol Álvarez-González Samuel Estrada-Soto Blanca Bazán-Perkins Blanca Bazán-Perkins |
| author_facet | Mayra D. Álvarez-Santos Marisol Álvarez-González Samuel Estrada-Soto Blanca Bazán-Perkins Blanca Bazán-Perkins |
| author_sort | Mayra D. Álvarez-Santos |
| collection | DOAJ |
| description | Smooth muscle is a central structure involved in the regulation of airway tone. In addition, it plays an important role in the development of some pathologies generated by alterations in contraction, such as hypercontractility and the airway hyperresponsiveness observed in asthma. The molecular processes associated with smooth muscle contraction are centered around myosin light chain (MLC) phosphorylation, which is controlled by a balance in the activity of myosin light-chain kinase (MLCK) and myosin light-chain phosphatase (MLCP). MLCK activation depends on increasing concentrations of intracellular Ca2+, while MLCP activation is independent of Ca2+. MLCP contains a phosphatase subunit (PP1c) that is regulated through myosin phosphatase target subunit 1 (MYPT1) and other subunits, such as glycogen-associated regulatory subunit and myosin-binding subunit 85 kDa. Interestingly, MLCP inhibition may contribute to exacerbation of smooth muscle contraction by increasing MLC phosphorylation to induce hypercontractility. Many pathways inhibiting MLCP activity in airway smooth muscle have been proposed and are focused on inhibition of PP1c, inhibitory phosphorylation of MYPT1 and dissociation of the PP1c-MYPT1 complex. |
| first_indexed | 2024-12-12T02:28:11Z |
| format | Article |
| id | doaj.art-d03147535be24cc180eec2482d5f5c4d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T02:28:11Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-d03147535be24cc180eec2482d5f5c4d2022-12-22T00:41:29ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-06-011110.3389/fphys.2020.00701501071Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle HypercontractilityMayra D. Álvarez-Santos0Marisol Álvarez-González1Samuel Estrada-Soto2Blanca Bazán-Perkins3Blanca Bazán-Perkins4Biology Area, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, MexicoLaboratorio de Inmunofarmacología, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, MexicoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, MexicoLaboratorio de Inmunofarmacología, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, MexicoTecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, MexicoSmooth muscle is a central structure involved in the regulation of airway tone. In addition, it plays an important role in the development of some pathologies generated by alterations in contraction, such as hypercontractility and the airway hyperresponsiveness observed in asthma. The molecular processes associated with smooth muscle contraction are centered around myosin light chain (MLC) phosphorylation, which is controlled by a balance in the activity of myosin light-chain kinase (MLCK) and myosin light-chain phosphatase (MLCP). MLCK activation depends on increasing concentrations of intracellular Ca2+, while MLCP activation is independent of Ca2+. MLCP contains a phosphatase subunit (PP1c) that is regulated through myosin phosphatase target subunit 1 (MYPT1) and other subunits, such as glycogen-associated regulatory subunit and myosin-binding subunit 85 kDa. Interestingly, MLCP inhibition may contribute to exacerbation of smooth muscle contraction by increasing MLC phosphorylation to induce hypercontractility. Many pathways inhibiting MLCP activity in airway smooth muscle have been proposed and are focused on inhibition of PP1c, inhibitory phosphorylation of MYPT1 and dissociation of the PP1c-MYPT1 complex.https://www.frontiersin.org/article/10.3389/fphys.2020.00701/fullkinase network in contractionphosphatase subunit 1cmyosin phosphatase target subunit 1contractionmyosin phosphatase |
| spellingShingle | Mayra D. Álvarez-Santos Marisol Álvarez-González Samuel Estrada-Soto Blanca Bazán-Perkins Blanca Bazán-Perkins Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility Frontiers in Physiology kinase network in contraction phosphatase subunit 1c myosin phosphatase target subunit 1 contraction myosin phosphatase |
| title | Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility |
| title_full | Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility |
| title_fullStr | Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility |
| title_full_unstemmed | Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility |
| title_short | Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility |
| title_sort | regulation of myosin light chain phosphatase activity to generate airway smooth muscle hypercontractility |
| topic | kinase network in contraction phosphatase subunit 1c myosin phosphatase target subunit 1 contraction myosin phosphatase |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00701/full |
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