Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

The mitochondrial AAA (ATPase Associated with diverse cellular Activities) protein ATAD1 (in humans; Msp1 in yeast) removes mislocalized membrane proteins, as well as stuck import substrates from the mitochondrial outer membrane, facilitating their re-insertion into their cognate organelles and main...

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Bibliographic Details
Main Authors: Lan Wang, Hannah Toutkoushian, Vladislav Belyy, Claire Y Kokontis, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
mitochondria
protein quality control
AAA proteins
tail-anchored proteins
protein mislocalization
cryo-EM
Online Access:https://elifesciences.org/articles/73941

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