Cow milk αs1-casein induces allergic responses in a mouse model of atopy
ABSTRACT: αs1-Casein is a potential allergen to induce hypersensitivity in cow milk. We had identified αs1-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of αs1-casein in a BALB/c mouse model. The levels of specific IgE, mast cell proteinase,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000441 |
| _version_ | 1826829902204108800 |
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| author | Guangyu Wang Xiaofeng Yu Yanjun Cong Linfeng Li |
| author_facet | Guangyu Wang Xiaofeng Yu Yanjun Cong Linfeng Li |
| author_sort | Guangyu Wang |
| collection | DOAJ |
| description | ABSTRACT: αs1-Casein is a potential allergen to induce hypersensitivity in cow milk. We had identified αs1-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of αs1-casein in a BALB/c mouse model. The levels of specific IgE, mast cell proteinase, histamine and cytokines in sensitized mice were determined, and the clinical and pathological observation were evaluated. Results showed that the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 increased significantly with a dose-dependent trend. The local alveolar septum collapsed or thickened, and lymphatic foci were produced in the spleen and thymus, and the inflammatory cells infiltrated in small intestinal mucosa mesenchyme. In conclusion, the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 and some inflammatory factors could possibly serve as allergic biomarkers of αs1-casein, however, additional studies on signal transduction and gene expression are necessary in future. |
| first_indexed | 2024-03-12T09:27:43Z |
| format | Article |
| id | doaj.art-d034beadce824e03a5e9aaee5b319f3b |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2025-02-16T09:22:52Z |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-d034beadce824e03a5e9aaee5b319f3b2025-02-03T05:16:11ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111512821289Cow milk αs1-casein induces allergic responses in a mouse model of atopyGuangyu Wang0Xiaofeng Yu1Yanjun Cong2Linfeng Li3Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China; Corresponding author at: College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.Department of Dermatology, Beijing Friendship Hospital, Beijing 100050, ChinaABSTRACT: αs1-Casein is a potential allergen to induce hypersensitivity in cow milk. We had identified αs1-casein and its epitopes in previous studies. The present study aimed to evaluate the allergic mechanism of αs1-casein in a BALB/c mouse model. The levels of specific IgE, mast cell proteinase, histamine and cytokines in sensitized mice were determined, and the clinical and pathological observation were evaluated. Results showed that the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 increased significantly with a dose-dependent trend. The local alveolar septum collapsed or thickened, and lymphatic foci were produced in the spleen and thymus, and the inflammatory cells infiltrated in small intestinal mucosa mesenchyme. In conclusion, the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 and some inflammatory factors could possibly serve as allergic biomarkers of αs1-casein, however, additional studies on signal transduction and gene expression are necessary in future.http://www.sciencedirect.com/science/article/pii/S2213453022000441Cow milkαs1-CaseinAllergenBALB/c mouse modelAllergic mechanism |
| spellingShingle | Guangyu Wang Xiaofeng Yu Yanjun Cong Linfeng Li Cow milk αs1-casein induces allergic responses in a mouse model of atopy Food Science and Human Wellness Cow milk αs1-Casein Allergen BALB/c mouse model Allergic mechanism |
| title | Cow milk αs1-casein induces allergic responses in a mouse model of atopy |
| title_full | Cow milk αs1-casein induces allergic responses in a mouse model of atopy |
| title_fullStr | Cow milk αs1-casein induces allergic responses in a mouse model of atopy |
| title_full_unstemmed | Cow milk αs1-casein induces allergic responses in a mouse model of atopy |
| title_short | Cow milk αs1-casein induces allergic responses in a mouse model of atopy |
| title_sort | cow milk αs1 casein induces allergic responses in a mouse model of atopy |
| topic | Cow milk αs1-Casein Allergen BALB/c mouse model Allergic mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000441 |
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