Fibroblasts as Modulators of Local and Systemic Cancer Metabolism
Fibroblast activation is an accompanying feature of solid tumor progression, resembling a conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous and plastic population with increasingly appreciated roles in tumor growth, metastatic capacity, and respo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/5/619 |
| _version_ | 1797762970915176448 |
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| author | Hannah Sanford-Crane Jaime Abrego Mara H. Sherman |
| author_facet | Hannah Sanford-Crane Jaime Abrego Mara H. Sherman |
| author_sort | Hannah Sanford-Crane |
| collection | DOAJ |
| description | Fibroblast activation is an accompanying feature of solid tumor progression, resembling a conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous and plastic population with increasingly appreciated roles in tumor growth, metastatic capacity, and response to therapy. Classical features of fibroblasts in a wound-healing response, including profound extracellular matrix production and cytokine release, are recapitulated in cancer. Emerging evidence suggests that fibroblastic cells in the microenvironments of solid tumors also critically modulate cellular metabolism in the neoplastic compartment through mechanisms including paracrine transfer of metabolites or non-cell-autonomous regulation of metabolic signaling pathways. These metabolic functions may represent common mechanisms by which fibroblasts stimulate growth of the regenerating epithelium during a wound-healing reaction, or may reflect unique co-evolution of cancer cells and surrounding stroma within the tumor microenvironment. Here we review the recent literature supporting an important role for CAFs in regulation of cancer cell metabolism, and relevant pathways that may serve as targets for therapeutic intervention. |
| first_indexed | 2024-03-12T19:34:55Z |
| format | Article |
| id | doaj.art-d036aa450c2c4e7ba2fa86367a4be8b6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:34:55Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d036aa450c2c4e7ba2fa86367a4be8b62023-08-02T04:17:01ZengMDPI AGCancers2072-66942019-05-0111561910.3390/cancers11050619cancers11050619Fibroblasts as Modulators of Local and Systemic Cancer MetabolismHannah Sanford-Crane0Jaime Abrego1Mara H. Sherman2Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USADepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USADepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USAFibroblast activation is an accompanying feature of solid tumor progression, resembling a conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous and plastic population with increasingly appreciated roles in tumor growth, metastatic capacity, and response to therapy. Classical features of fibroblasts in a wound-healing response, including profound extracellular matrix production and cytokine release, are recapitulated in cancer. Emerging evidence suggests that fibroblastic cells in the microenvironments of solid tumors also critically modulate cellular metabolism in the neoplastic compartment through mechanisms including paracrine transfer of metabolites or non-cell-autonomous regulation of metabolic signaling pathways. These metabolic functions may represent common mechanisms by which fibroblasts stimulate growth of the regenerating epithelium during a wound-healing reaction, or may reflect unique co-evolution of cancer cells and surrounding stroma within the tumor microenvironment. Here we review the recent literature supporting an important role for CAFs in regulation of cancer cell metabolism, and relevant pathways that may serve as targets for therapeutic intervention.https://www.mdpi.com/2072-6694/11/5/619cancer-associated fibroblastcancer metabolismtumor-stroma crosstalk |
| spellingShingle | Hannah Sanford-Crane Jaime Abrego Mara H. Sherman Fibroblasts as Modulators of Local and Systemic Cancer Metabolism Cancers cancer-associated fibroblast cancer metabolism tumor-stroma crosstalk |
| title | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism |
| title_full | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism |
| title_fullStr | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism |
| title_full_unstemmed | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism |
| title_short | Fibroblasts as Modulators of Local and Systemic Cancer Metabolism |
| title_sort | fibroblasts as modulators of local and systemic cancer metabolism |
| topic | cancer-associated fibroblast cancer metabolism tumor-stroma crosstalk |
| url | https://www.mdpi.com/2072-6694/11/5/619 |
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