Leveraging the placenta to advance neonatal care
The impact of placental dysfunction and placental injury on the fetus and newborn infant has become a topic of growing interest in neonatal disease research. However, the use of placental pathology in directing or influencing neonatal clinical management continues to be limited for a wide range of r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1174174/full |
| _version_ | 1797826866711625728 |
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| author | Karen K. Mestan Karen K. Mestan Sandra L. Leibel Sandra L. Leibel Eniko Sajti Eniko Sajti Betty Pham Betty Pham Samantha Hietalati Samantha Hietalati Louise Laurent Louise Laurent Mana Parast Mana Parast |
| author_facet | Karen K. Mestan Karen K. Mestan Sandra L. Leibel Sandra L. Leibel Eniko Sajti Eniko Sajti Betty Pham Betty Pham Samantha Hietalati Samantha Hietalati Louise Laurent Louise Laurent Mana Parast Mana Parast |
| author_sort | Karen K. Mestan |
| collection | DOAJ |
| description | The impact of placental dysfunction and placental injury on the fetus and newborn infant has become a topic of growing interest in neonatal disease research. However, the use of placental pathology in directing or influencing neonatal clinical management continues to be limited for a wide range of reasons, some of which are historical and thus easily overcome today. In this review, we summarize the most recent literature linking placental function to neonatal outcomes, focusing on clinical placental pathology findings and the most common neonatal diagnoses that have been associated with placental dysfunction. We discuss how recent technological advances in neonatal and perinatal medicine may allow us to make a paradigm shift, in which valuable information provided by the placenta could be used to guide neonatal management more effectively, and to ultimately enhance neonatal care in order to improve our patient outcomes. We propose new avenues of clinical management in which the placenta could serve as a diagnostic tool toward more personalized neonatal intensive care unit management. |
| first_indexed | 2024-04-09T12:39:08Z |
| format | Article |
| id | doaj.art-d036ac457e144e54b227bfb8471d7d4b |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T12:39:08Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-d036ac457e144e54b227bfb8471d7d4b2023-05-15T04:55:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-05-011110.3389/fped.2023.11741741174174Leveraging the placenta to advance neonatal careKaren K. Mestan0Karen K. Mestan1Sandra L. Leibel2Sandra L. Leibel3Eniko Sajti4Eniko Sajti5Betty Pham6Betty Pham7Samantha Hietalati8Samantha Hietalati9Louise Laurent10Louise Laurent11Mana Parast12Mana Parast13Department of Pediatrics/Division of Neonatology, University of California, San Diego School of Medicine, La Jolla, CA, USADepartment of Pediatrics/Division of Neonatology, Rady Children's Hospital of San Diego, San Diego, CA, USADepartment of Pediatrics/Division of Neonatology, University of California, San Diego School of Medicine, La Jolla, CA, USADepartment of Pediatrics/Division of Neonatology, Rady Children's Hospital of San Diego, San Diego, CA, USADepartment of Pediatrics/Division of Neonatology, University of California, San Diego School of Medicine, La Jolla, CA, USADepartment of Pediatrics/Division of Neonatology, Rady Children's Hospital of San Diego, San Diego, CA, USADepartment of Pediatrics/Division of Neonatology, University of California, San Diego School of Medicine, La Jolla, CA, USADepartment of Pediatrics/Division of Neonatology, Rady Children's Hospital of San Diego, San Diego, CA, USADepartment of Pediatrics/Division of Neonatology, University of California, San Diego School of Medicine, La Jolla, CA, USADepartment of Pediatrics/Division of Neonatology, Rady Children's Hospital of San Diego, San Diego, CA, USADepartment of Obstetrics, Gynecology and Reproductive Sciences/Division of Maternal Fetal Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USASanford Consortium for Regenerative Medicine, La Jolla, CA, USASanford Consortium for Regenerative Medicine, La Jolla, CA, USADepartment of Pathology, University of California, San Diego School ofMedicine, La Jolla, CA, USAThe impact of placental dysfunction and placental injury on the fetus and newborn infant has become a topic of growing interest in neonatal disease research. However, the use of placental pathology in directing or influencing neonatal clinical management continues to be limited for a wide range of reasons, some of which are historical and thus easily overcome today. In this review, we summarize the most recent literature linking placental function to neonatal outcomes, focusing on clinical placental pathology findings and the most common neonatal diagnoses that have been associated with placental dysfunction. We discuss how recent technological advances in neonatal and perinatal medicine may allow us to make a paradigm shift, in which valuable information provided by the placenta could be used to guide neonatal management more effectively, and to ultimately enhance neonatal care in order to improve our patient outcomes. We propose new avenues of clinical management in which the placenta could serve as a diagnostic tool toward more personalized neonatal intensive care unit management.https://www.frontiersin.org/articles/10.3389/fped.2023.1174174/fullneonatal intensive care unit (NICU)placental pathologyprematurity and low birth weightpreeclampsiabronchopulmonary dysplasia (BPD)chorioamnionitis |
| spellingShingle | Karen K. Mestan Karen K. Mestan Sandra L. Leibel Sandra L. Leibel Eniko Sajti Eniko Sajti Betty Pham Betty Pham Samantha Hietalati Samantha Hietalati Louise Laurent Louise Laurent Mana Parast Mana Parast Leveraging the placenta to advance neonatal care Frontiers in Pediatrics neonatal intensive care unit (NICU) placental pathology prematurity and low birth weight preeclampsia bronchopulmonary dysplasia (BPD) chorioamnionitis |
| title | Leveraging the placenta to advance neonatal care |
| title_full | Leveraging the placenta to advance neonatal care |
| title_fullStr | Leveraging the placenta to advance neonatal care |
| title_full_unstemmed | Leveraging the placenta to advance neonatal care |
| title_short | Leveraging the placenta to advance neonatal care |
| title_sort | leveraging the placenta to advance neonatal care |
| topic | neonatal intensive care unit (NICU) placental pathology prematurity and low birth weight preeclampsia bronchopulmonary dysplasia (BPD) chorioamnionitis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1174174/full |
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