Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report
Abstract Background A limited number of studies have described thrombotic complications in pregnant women with COVID-19. Here we report on fatal pulmonary embolism in a pregnant woman with laboratory confirmed SARS-CoV-2 infection. Case presentation A 28-year-old Kazakh woman was hospitalized with m...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04180-w |
| _version_ | 1797452545642201088 |
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| author | Yuliya V. Perfilyeva Saule B. Maukayeva Yerbol M. Smail Andrey M. Dmitrovskiy Yekaterina O. Ostapchuk Andrey V. Zhigailov Anna S. Nizkorodova Zhanna A. Berdygulova Dinara A. Naizabayeva Anastassiya V. Perfilyeva Elina R. Maltseva Kulyan Zh. Kamytbekova Yuriy A. Skiba |
| author_facet | Yuliya V. Perfilyeva Saule B. Maukayeva Yerbol M. Smail Andrey M. Dmitrovskiy Yekaterina O. Ostapchuk Andrey V. Zhigailov Anna S. Nizkorodova Zhanna A. Berdygulova Dinara A. Naizabayeva Anastassiya V. Perfilyeva Elina R. Maltseva Kulyan Zh. Kamytbekova Yuriy A. Skiba |
| author_sort | Yuliya V. Perfilyeva |
| collection | DOAJ |
| description | Abstract Background A limited number of studies have described thrombotic complications in pregnant women with COVID-19. Here we report on fatal pulmonary embolism in a pregnant woman with laboratory confirmed SARS-CoV-2 infection. Case presentation A 28-year-old Kazakh woman was hospitalized with muscle pain, dry cough and a temperature of 37.5 °C at the 29th week of gestation. Upon admission, a blood test demonstrated elevated neutrophil-to-lymphocyte ratio, decreased levels of erythrocytes and hemoglobin, as well as prolonged prothrombin and activated partial thromboplastin time. Within 14 days of admission, she experienced respiratory distress and underwent transfer to the intensive care unit, intubation and a cesarean section. The patient received intravenous antibiotics, antiviral medications, systemic corticosteroids and dual anticoagulation with aspirin and enoxaparin. Death outcome was reported on day 18 of illness despite aggressive supportive care. Histological analysis demonstrated that obstruction of the main pulmonary arthery and disseminated intravascular coagulation were the causes of death. Conclusions This case demonstrates that in the management of pregnancy and childbirth in patients with suspected or confirmed COVID-19 infection, special attention should be paid to coagulation system parameters and timely appropriate prophylaxis of thromboembolic complications, which has yet to be determined. |
| first_indexed | 2024-03-09T15:10:15Z |
| format | Article |
| id | doaj.art-d0374d8ad2bc4ffcb7afc2e70b0fb1f2 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-09T15:10:15Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-d0374d8ad2bc4ffcb7afc2e70b0fb1f22023-11-26T13:26:15ZengBMCJournal of Medical Case Reports1752-19472023-11-011711810.1186/s13256-023-04180-wLethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case reportYuliya V. Perfilyeva0Saule B. Maukayeva1Yerbol M. Smail2Andrey M. Dmitrovskiy3Yekaterina O. Ostapchuk4Andrey V. Zhigailov5Anna S. Nizkorodova6Zhanna A. Berdygulova7Dinara A. Naizabayeva8Anastassiya V. Perfilyeva9Elina R. Maltseva10Kulyan Zh. Kamytbekova11Yuriy A. Skiba12Almaty Branch of the National Center for Biotechnology, Central Reference LaboratorySemey Medical UniversitySemey Medical UniversityAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryInstitute of Genetics and CytologyAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratorySouth-Kazakhstan Medical AcademyAlmaty Branch of the National Center for Biotechnology, Central Reference LaboratoryAbstract Background A limited number of studies have described thrombotic complications in pregnant women with COVID-19. Here we report on fatal pulmonary embolism in a pregnant woman with laboratory confirmed SARS-CoV-2 infection. Case presentation A 28-year-old Kazakh woman was hospitalized with muscle pain, dry cough and a temperature of 37.5 °C at the 29th week of gestation. Upon admission, a blood test demonstrated elevated neutrophil-to-lymphocyte ratio, decreased levels of erythrocytes and hemoglobin, as well as prolonged prothrombin and activated partial thromboplastin time. Within 14 days of admission, she experienced respiratory distress and underwent transfer to the intensive care unit, intubation and a cesarean section. The patient received intravenous antibiotics, antiviral medications, systemic corticosteroids and dual anticoagulation with aspirin and enoxaparin. Death outcome was reported on day 18 of illness despite aggressive supportive care. Histological analysis demonstrated that obstruction of the main pulmonary arthery and disseminated intravascular coagulation were the causes of death. Conclusions This case demonstrates that in the management of pregnancy and childbirth in patients with suspected or confirmed COVID-19 infection, special attention should be paid to coagulation system parameters and timely appropriate prophylaxis of thromboembolic complications, which has yet to be determined.https://doi.org/10.1186/s13256-023-04180-wCOVID-19PregnancyPulmonary Artery EmbolismLethal Outcome |
| spellingShingle | Yuliya V. Perfilyeva Saule B. Maukayeva Yerbol M. Smail Andrey M. Dmitrovskiy Yekaterina O. Ostapchuk Andrey V. Zhigailov Anna S. Nizkorodova Zhanna A. Berdygulova Dinara A. Naizabayeva Anastassiya V. Perfilyeva Elina R. Maltseva Kulyan Zh. Kamytbekova Yuriy A. Skiba Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report Journal of Medical Case Reports COVID-19 Pregnancy Pulmonary Artery Embolism Lethal Outcome |
| title | Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report |
| title_full | Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report |
| title_fullStr | Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report |
| title_full_unstemmed | Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report |
| title_short | Lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus-2 receiving prophylactic anticoagulation: a case report |
| title_sort | lethal pulmonary embolism in a pregnant woman with severe acute respiratory syndrome coronavirus 2 receiving prophylactic anticoagulation a case report |
| topic | COVID-19 Pregnancy Pulmonary Artery Embolism Lethal Outcome |
| url | https://doi.org/10.1186/s13256-023-04180-w |
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