Chronic stress in solid tumor development: from mechanisms to interventions
Abstract Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have sh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-023-00903-9 |
| _version_ | 1811175776368721920 |
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| author | Jiajing Yan Yibing Chen Minhua Luo Xinyu Hu Hongsheng Li Quentin Liu Zhengzhi Zou |
| author_facet | Jiajing Yan Yibing Chen Minhua Luo Xinyu Hu Hongsheng Li Quentin Liu Zhengzhi Zou |
| author_sort | Jiajing Yan |
| collection | DOAJ |
| description | Abstract Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells. Current clinical evidences also suggest that chronic stress affects the outcome of cancer treatment. However, in clinic, there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, and apoptotic resistance), metabolic reprogramming and immune escape, and peritumor neuromodulation. Based on the current clinical treatment framework for cancer and chronic stress, we also summarize pharmacological and non-pharmacological therapeutic approaches to provide some directions for cancer therapy. |
| first_indexed | 2024-04-10T19:41:24Z |
| format | Article |
| id | doaj.art-d039123211c046e398051fb1238d5349 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-10T19:41:24Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-d039123211c046e398051fb1238d53492023-01-29T12:18:30ZengBMCJournal of Biomedical Science1423-01272023-01-0130112510.1186/s12929-023-00903-9Chronic stress in solid tumor development: from mechanisms to interventionsJiajing Yan0Yibing Chen1Minhua Luo2Xinyu Hu3Hongsheng Li4Quentin Liu5Zhengzhi Zou6MOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal UniversityDepartment of Gynecology and Obstetrics, First Affiliated Hospital, Genetic and Prenatal Diagnosis Center, Zhengzhou UniversityMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal UniversityMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal UniversityDepartment of Breast Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterMOE Key Laboratory of Laser Life Science & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal UniversityAbstract Chronic stress results in disturbances of body hormones through the neuroendocrine system. Cancer patients often experience recurrent anxiety and restlessness during disease progression and treatment, which aggravates disease progression and hinders treatment effects. Recent studies have shown that chronic stress-regulated neuroendocrine systems secret hormones to activate many signaling pathways related to tumor development in tumor cells. The activated neuroendocrine system acts not only on tumor cells but also modulates the survival and metabolic changes of surrounding non-cancerous cells. Current clinical evidences also suggest that chronic stress affects the outcome of cancer treatment. However, in clinic, there is lack of effective treatment for chronic stress in cancer patients. In this review, we discuss the main mechanisms by which chronic stress regulates the tumor microenvironment, including functional regulation of tumor cells by stress hormones (stem cell-like properties, metastasis, angiogenesis, DNA damage accumulation, and apoptotic resistance), metabolic reprogramming and immune escape, and peritumor neuromodulation. Based on the current clinical treatment framework for cancer and chronic stress, we also summarize pharmacological and non-pharmacological therapeutic approaches to provide some directions for cancer therapy.https://doi.org/10.1186/s12929-023-00903-9Chronic stressTumor developmentTumor microenvironmentCancer treatment |
| spellingShingle | Jiajing Yan Yibing Chen Minhua Luo Xinyu Hu Hongsheng Li Quentin Liu Zhengzhi Zou Chronic stress in solid tumor development: from mechanisms to interventions Journal of Biomedical Science Chronic stress Tumor development Tumor microenvironment Cancer treatment |
| title | Chronic stress in solid tumor development: from mechanisms to interventions |
| title_full | Chronic stress in solid tumor development: from mechanisms to interventions |
| title_fullStr | Chronic stress in solid tumor development: from mechanisms to interventions |
| title_full_unstemmed | Chronic stress in solid tumor development: from mechanisms to interventions |
| title_short | Chronic stress in solid tumor development: from mechanisms to interventions |
| title_sort | chronic stress in solid tumor development from mechanisms to interventions |
| topic | Chronic stress Tumor development Tumor microenvironment Cancer treatment |
| url | https://doi.org/10.1186/s12929-023-00903-9 |
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