Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other
Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells. There are multiple layers of interaction between these immune cell po...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221287782200134X |
| _version_ | 1818057184894779392 |
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| author | Martin G. Scherm Rebecca C. Wyatt Isabelle Serr David Anz Sarah J. Richardson Carolin Daniel |
| author_facet | Martin G. Scherm Rebecca C. Wyatt Isabelle Serr David Anz Sarah J. Richardson Carolin Daniel |
| author_sort | Martin G. Scherm |
| collection | DOAJ |
| description | Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells. There are multiple layers of interaction between these immune cell populations and the pancreatic islets. Scope of review: In this review article, we aim to discuss important recent insights into the multiple layers of interaction between immune cell populations and the pancreatic islets. Specifically, we discuss the environment where immune and beta cell interactions occur, the key cell types and molecules involved, and the outcomes of these interactions. Major conclusions: Most of the molecular mechanisms underlying aberrant immune cell activation and impaired immune tolerance remain insufficiently understood, which hinders the development of efficient prevention and treatment strategies. In order to overcome this knowledge gap, a better understanding of the complex interactions of immune cells and beta cells, including both the underlying protective and pathogenic mechanisms is urgently required. |
| first_indexed | 2024-12-10T12:40:42Z |
| format | Article |
| id | doaj.art-d03c0f094db1468697639ac277d719fa |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-12-10T12:40:42Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-d03c0f094db1468697639ac277d719fa2022-12-22T01:48:32ZengElsevierMolecular Metabolism2212-87782022-10-0164101565Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each otherMartin G. Scherm0Rebecca C. Wyatt1Isabelle Serr2David Anz3Sarah J. Richardson4Carolin Daniel5Institute of Diabetes Research, Group Immune Tolerance Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung (DZD), Ingolstaedter Landstrasse 1, 85764 Munich-Neuherberg, GermanyIslet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), University of Exeter College of Medicine and Health, Exeter EX2 5DW, UKInstitute of Diabetes Research, Group Immune Tolerance Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung (DZD), Ingolstaedter Landstrasse 1, 85764 Munich-Neuherberg, GermanyDepartment of Internal Medicine II (Gastroenterology and Hepatology), Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany; Division of Clinical Pharmacology, Department of Medicine IV, Ludwig-Maximilians-Universität München, 80337 Munich, GermanyIslet Biology Group (IBEx), Exeter Centre of Excellence in Diabetes (EXCEED), University of Exeter College of Medicine and Health, Exeter EX2 5DW, UKInstitute of Diabetes Research, Group Immune Tolerance Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939 Munich, Germany; Deutsches Zentrum für Diabetesforschung (DZD), Ingolstaedter Landstrasse 1, 85764 Munich-Neuherberg, Germany; Division of Clinical Pharmacology, Department of Medicine IV, Ludwig-Maximilians-Universität München, 80337 Munich, Germany; Corresponding author. Institute of Diabetes Research, Group Immune Tolerance Type 1 Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, Heidemannstrasse 1, 80939 Munich, Germany.Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells. There are multiple layers of interaction between these immune cell populations and the pancreatic islets. Scope of review: In this review article, we aim to discuss important recent insights into the multiple layers of interaction between immune cell populations and the pancreatic islets. Specifically, we discuss the environment where immune and beta cell interactions occur, the key cell types and molecules involved, and the outcomes of these interactions. Major conclusions: Most of the molecular mechanisms underlying aberrant immune cell activation and impaired immune tolerance remain insufficiently understood, which hinders the development of efficient prevention and treatment strategies. In order to overcome this knowledge gap, a better understanding of the complex interactions of immune cells and beta cells, including both the underlying protective and pathogenic mechanisms is urgently required.http://www.sciencedirect.com/science/article/pii/S221287782200134XType 1 diabetesAutoimmunityAutoimmune diabetesBeta cellsImmune cellsImmune Regulation |
| spellingShingle | Martin G. Scherm Rebecca C. Wyatt Isabelle Serr David Anz Sarah J. Richardson Carolin Daniel Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other Molecular Metabolism Type 1 diabetes Autoimmunity Autoimmune diabetes Beta cells Immune cells Immune Regulation |
| title | Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other |
| title_full | Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other |
| title_fullStr | Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other |
| title_full_unstemmed | Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other |
| title_short | Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other |
| title_sort | beta cell and immune cell interactions in autoimmune type 1 diabetes how they meet and talk to each other |
| topic | Type 1 diabetes Autoimmunity Autoimmune diabetes Beta cells Immune cells Immune Regulation |
| url | http://www.sciencedirect.com/science/article/pii/S221287782200134X |
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