The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review
Background: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6364 |
| _version_ | 1797506337690615808 |
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| author | Amy L. Shaver Swapnil Sharma Nikita Nikita Daniel S. Lefler Atrayee Basu-Mallick Jennifer M. Johnson Meghan Butryn Grace Lu-Yao |
| author_facet | Amy L. Shaver Swapnil Sharma Nikita Nikita Daniel S. Lefler Atrayee Basu-Mallick Jennifer M. Johnson Meghan Butryn Grace Lu-Yao |
| author_sort | Amy L. Shaver |
| collection | DOAJ |
| description | Background: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy. Method: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results. Results: In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria. Conclusion: Existing evidence supports that physical activity is associated with decreased treatment-related toxicities such as CRF. However, further investigation is warranted. The dearth of clinical studies illustrates the need for more research to address this question, to guide patients and their providers in the application of appropriate physical activity interventions in those patients undergoing ICI. |
| first_indexed | 2024-03-10T04:32:09Z |
| format | Article |
| id | doaj.art-d03da42ec3e04552bab52d5c88a79e71 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:32:09Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d03da42ec3e04552bab52d5c88a79e712023-11-23T04:07:44ZengMDPI AGCancers2072-66942021-12-011324636410.3390/cancers13246364The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping ReviewAmy L. Shaver0Swapnil Sharma1Nikita Nikita2Daniel S. Lefler3Atrayee Basu-Mallick4Jennifer M. Johnson5Meghan Butryn6Grace Lu-Yao7Department of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USADepartment of Psychology, Drexel University, Philadelphia, PA 19104, USADepartment of Medical Oncology, Sidney Kimmel Cancer Center at Jefferson, Sidney Kimmel Medical College, Philadelphia, PA 19107, USABackground: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy. Method: Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results. Results: In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria. Conclusion: Existing evidence supports that physical activity is associated with decreased treatment-related toxicities such as CRF. However, further investigation is warranted. The dearth of clinical studies illustrates the need for more research to address this question, to guide patients and their providers in the application of appropriate physical activity interventions in those patients undergoing ICI.https://www.mdpi.com/2072-6694/13/24/6364immune checkpoint inhibitorsphysical activityexerciseexercise therapyadverse eventstumor growth |
| spellingShingle | Amy L. Shaver Swapnil Sharma Nikita Nikita Daniel S. Lefler Atrayee Basu-Mallick Jennifer M. Johnson Meghan Butryn Grace Lu-Yao The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review Cancers immune checkpoint inhibitors physical activity exercise exercise therapy adverse events tumor growth |
| title | The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review |
| title_full | The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review |
| title_fullStr | The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review |
| title_full_unstemmed | The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review |
| title_short | The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review |
| title_sort | effects of physical activity on cancer patients undergoing treatment with immune checkpoint inhibitors a scoping review |
| topic | immune checkpoint inhibitors physical activity exercise exercise therapy adverse events tumor growth |
| url | https://www.mdpi.com/2072-6694/13/24/6364 |
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