Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD
Temporal processing (TP) is associated with functions such as perception, verbal skills, temporal perspective, and future planning, and is intercorrelated with working memory, attention, and inhibitory control, which are highly impaired in individuals with attention deficit hyperactivity disorder (A...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/9/1218 |
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| author | Johan E. Acosta-López Isabel Suárez David A. Pineda Martha L. Cervantes-Henríquez Martha L. Martínez-Banfi Semiramis G. Lozano-Gutiérrez Mostapha Ahmad Wilmar Pineda-Alhucema Luz M. Noguera-Machacón Moisés De La Hoz Elsy Mejía-Segura Giomar Jiménez-Figueroa Manuel Sánchez-Rojas Claudio A. Mastronardi Mauricio Arcos-Burgos Jorge I. Vélez Pedro J. Puentes-Rozo |
| author_facet | Johan E. Acosta-López Isabel Suárez David A. Pineda Martha L. Cervantes-Henríquez Martha L. Martínez-Banfi Semiramis G. Lozano-Gutiérrez Mostapha Ahmad Wilmar Pineda-Alhucema Luz M. Noguera-Machacón Moisés De La Hoz Elsy Mejía-Segura Giomar Jiménez-Figueroa Manuel Sánchez-Rojas Claudio A. Mastronardi Mauricio Arcos-Burgos Jorge I. Vélez Pedro J. Puentes-Rozo |
| author_sort | Johan E. Acosta-López |
| collection | DOAJ |
| description | Temporal processing (TP) is associated with functions such as perception, verbal skills, temporal perspective, and future planning, and is intercorrelated with working memory, attention, and inhibitory control, which are highly impaired in individuals with attention deficit hyperactivity disorder (ADHD). Here we evaluate TP measures as potential endophenotypes in Caribbean families ascertained from probands affected by ADHD. A total of 232 individuals were recruited and clinically evaluated using an extensive battery of neuropsychological tasks and reaction time (RT)-based task paradigms. Further, the heritability (genetic variance underpinning phenotype) was estimated as a measure of the genetics apportionment. A predictive framework for ADHD diagnosis was derived using these tasks. We found that individuals with ADHD differed from controls in neuropsychological tasks assessing mental control, visual-verbal memory, verbal fluency, verbal, and semantic fluency. In addition, TP measures such as RT, errors, and variability were also affected in individuals with ADHD. Moreover, we determined that only omission and commission errors had significant heritability. In conclusion, we have disentangled omission and commission errors as possible TP endophenotypes in ADHD, which can be suitable to assess the neurobiological and genetic basis of ADHD. A predictive model using these endophenotypes led to remarkable sensitivity, specificity, precision and classification rate for ADHD diagnosis, and may be a useful tool for patients’ diagnosis, follow-up, and longitudinal assessment in the clinical setting. |
| first_indexed | 2024-03-10T07:51:40Z |
| format | Article |
| id | doaj.art-d040ae2a1c5f4201991e98854ce780d8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T07:51:40Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d040ae2a1c5f4201991e98854ce780d82023-11-22T12:14:52ZengMDPI AGBrain Sciences2076-34252021-09-01119121810.3390/brainsci11091218Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHDJohan E. Acosta-López0Isabel Suárez1David A. Pineda2Martha L. Cervantes-Henríquez3Martha L. Martínez-Banfi4Semiramis G. Lozano-Gutiérrez5Mostapha Ahmad6Wilmar Pineda-Alhucema7Luz M. Noguera-Machacón8Moisés De La Hoz9Elsy Mejía-Segura10Giomar Jiménez-Figueroa11Manuel Sánchez-Rojas12Claudio A. Mastronardi13Mauricio Arcos-Burgos14Jorge I. Vélez15Pedro J. Puentes-Rozo16Facultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaUniversidad del Norte, Barranquilla 081007, ColombiaNeuropsychology and Conduct Research Group, University of San Buenaventura, Medellín 050010, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaINPAC Research Group, Fundación Universitaria Sanitas, Bogotá 111321, ColombiaGrupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, ColombiaUniversidad del Norte, Barranquilla 081007, ColombiaFacultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080005, ColombiaTemporal processing (TP) is associated with functions such as perception, verbal skills, temporal perspective, and future planning, and is intercorrelated with working memory, attention, and inhibitory control, which are highly impaired in individuals with attention deficit hyperactivity disorder (ADHD). Here we evaluate TP measures as potential endophenotypes in Caribbean families ascertained from probands affected by ADHD. A total of 232 individuals were recruited and clinically evaluated using an extensive battery of neuropsychological tasks and reaction time (RT)-based task paradigms. Further, the heritability (genetic variance underpinning phenotype) was estimated as a measure of the genetics apportionment. A predictive framework for ADHD diagnosis was derived using these tasks. We found that individuals with ADHD differed from controls in neuropsychological tasks assessing mental control, visual-verbal memory, verbal fluency, verbal, and semantic fluency. In addition, TP measures such as RT, errors, and variability were also affected in individuals with ADHD. Moreover, we determined that only omission and commission errors had significant heritability. In conclusion, we have disentangled omission and commission errors as possible TP endophenotypes in ADHD, which can be suitable to assess the neurobiological and genetic basis of ADHD. A predictive model using these endophenotypes led to remarkable sensitivity, specificity, precision and classification rate for ADHD diagnosis, and may be a useful tool for patients’ diagnosis, follow-up, and longitudinal assessment in the clinical setting.https://www.mdpi.com/2076-3425/11/9/1218ADHDendophenotypestemporal processingreaction timegeneticsCaribbean community |
| spellingShingle | Johan E. Acosta-López Isabel Suárez David A. Pineda Martha L. Cervantes-Henríquez Martha L. Martínez-Banfi Semiramis G. Lozano-Gutiérrez Mostapha Ahmad Wilmar Pineda-Alhucema Luz M. Noguera-Machacón Moisés De La Hoz Elsy Mejía-Segura Giomar Jiménez-Figueroa Manuel Sánchez-Rojas Claudio A. Mastronardi Mauricio Arcos-Burgos Jorge I. Vélez Pedro J. Puentes-Rozo Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD Brain Sciences ADHD endophenotypes temporal processing reaction time genetics Caribbean community |
| title | Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD |
| title_full | Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD |
| title_fullStr | Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD |
| title_full_unstemmed | Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD |
| title_short | Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD |
| title_sort | impulsive and omission errors potential temporal processing endophenotypes in adhd |
| topic | ADHD endophenotypes temporal processing reaction time genetics Caribbean community |
| url | https://www.mdpi.com/2076-3425/11/9/1218 |
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