Synaptic changes induced by cannabinoid drugs and cannabis use disorder
The legalization of cannabis in many countries, as well as the decrease in perceived risks of cannabis, have contributed to the increase in cannabis use medicinally and recreationally. Like many drugs of abuse, cannabis and cannabis-derived drugs are prone to misuse, and long-term usage can lead to...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122000614 |
| _version_ | 1828880208961208320 |
|---|---|
| author | Shana M. Augustin David M. Lovinger |
| author_facet | Shana M. Augustin David M. Lovinger |
| author_sort | Shana M. Augustin |
| collection | DOAJ |
| description | The legalization of cannabis in many countries, as well as the decrease in perceived risks of cannabis, have contributed to the increase in cannabis use medicinally and recreationally. Like many drugs of abuse, cannabis and cannabis-derived drugs are prone to misuse, and long-term usage can lead to drug tolerance and the development of Cannabis Use Disorder (CUD). These drugs signal through cannabinoid receptors, which are expressed in brain regions involved in the neural processing of reward, habit formation, and cognition. Despite the widespread use of cannabis and cannabinoids as therapeutic agents, little is known about the neurobiological mechanisms associated with CUD and cannabinoid drug use. In this article, we discuss the advances in research spanning animal models to humans on cannabis and synthetic cannabinoid actions on synaptic transmission, highlighting the neurobiological mechanisms following acute and chronic drug exposure. This article also highlights the need for more research elucidating the neurobiological mechanisms associated with CUD and cannabinoid drug use. |
| first_indexed | 2024-12-13T09:43:16Z |
| format | Article |
| id | doaj.art-d0433e0172964839bdd536ad58d45308 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-13T09:43:16Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-d0433e0172964839bdd536ad58d453082022-12-21T23:52:08ZengElsevierNeurobiology of Disease1095-953X2022-06-01167105670Synaptic changes induced by cannabinoid drugs and cannabis use disorderShana M. Augustin0David M. Lovinger1Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USALaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA; Corresponding author at: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room TS-13A, Rockville, MD 20852, USA.The legalization of cannabis in many countries, as well as the decrease in perceived risks of cannabis, have contributed to the increase in cannabis use medicinally and recreationally. Like many drugs of abuse, cannabis and cannabis-derived drugs are prone to misuse, and long-term usage can lead to drug tolerance and the development of Cannabis Use Disorder (CUD). These drugs signal through cannabinoid receptors, which are expressed in brain regions involved in the neural processing of reward, habit formation, and cognition. Despite the widespread use of cannabis and cannabinoids as therapeutic agents, little is known about the neurobiological mechanisms associated with CUD and cannabinoid drug use. In this article, we discuss the advances in research spanning animal models to humans on cannabis and synthetic cannabinoid actions on synaptic transmission, highlighting the neurobiological mechanisms following acute and chronic drug exposure. This article also highlights the need for more research elucidating the neurobiological mechanisms associated with CUD and cannabinoid drug use.http://www.sciencedirect.com/science/article/pii/S0969996122000614Cannabis sativaLong-term potentiationLong-term depressionSynaptic ModulationDelta-9 tetrahydrocannabinolCannabinoid 1 receptor |
| spellingShingle | Shana M. Augustin David M. Lovinger Synaptic changes induced by cannabinoid drugs and cannabis use disorder Neurobiology of Disease Cannabis sativa Long-term potentiation Long-term depression Synaptic Modulation Delta-9 tetrahydrocannabinol Cannabinoid 1 receptor |
| title | Synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| title_full | Synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| title_fullStr | Synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| title_full_unstemmed | Synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| title_short | Synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| title_sort | synaptic changes induced by cannabinoid drugs and cannabis use disorder |
| topic | Cannabis sativa Long-term potentiation Long-term depression Synaptic Modulation Delta-9 tetrahydrocannabinol Cannabinoid 1 receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122000614 |
| work_keys_str_mv | AT shanamaugustin synapticchangesinducedbycannabinoiddrugsandcannabisusedisorder AT davidmlovinger synapticchangesinducedbycannabinoiddrugsandcannabisusedisorder |