Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy.
<h4>Purpose</h4>To explore the effect of photodynamic therapy (PDT) on the choroid of medial area from optic disc and factors correlated with treatment outcomes, we evaluated choroidal changes using ultra-widefield optical coherence tomography (UWF-OCT) after PDT for central serous chori...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0282057 |
| _version_ | 1797860181918351360 |
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| author | Ryoh Funatsu Shozo Sonoda Hiroto Terasaki Hideki Shiihara Naohisa Mihara Juun Horie Taiji Sakamoto |
| author_facet | Ryoh Funatsu Shozo Sonoda Hiroto Terasaki Hideki Shiihara Naohisa Mihara Juun Horie Taiji Sakamoto |
| author_sort | Ryoh Funatsu |
| collection | DOAJ |
| description | <h4>Purpose</h4>To explore the effect of photodynamic therapy (PDT) on the choroid of medial area from optic disc and factors correlated with treatment outcomes, we evaluated choroidal changes using ultra-widefield optical coherence tomography (UWF-OCT) after PDT for central serous chorioretinopathy (CSC).<h4>Methods</h4>In this retrospective case-series, we included CSC patients who received a standard-dose of full-fluence PDT. UWF-OCT were examined at baseline and 3 months after treatment. We measured choroidal thickness (CT), classified into central, middle, and peripheral sectors. We examined CT changes after PDT by sectors and treatment outcome.<h4>Results</h4>Twenty-two eyes of 21 patients (20 males; mean age 58.7 ± 12.3 years) were included. CT reduction after PDT was significant in all sectors, including peripheral areas: supratemporal, 330.5 ± 90.6 μm vs. 237.0 ± 53.2 μm; infratemporal, 240.0 ± 89.4 μm vs. 209.9 ± 55.1 μm; supranasal, 237.7 ± 59.8 vs 209.3 ± 69.3 μm; infranasal, 172.6 ± 47.2 μm vs. 155.1 ± 38.2 μm (P < 0.001, for all). In patients with retinal fluid resolution, despite no apparent difference in baseline CT, there was more significant reduction after PDT in supratemporal and supranasal peripheral sectors, compared with patients without resolution: supratemporal, 41.9 ± 30.3 μm vs. -1.6 ± 22.7 μm; supranasal, 24.7 ± 15.3 μm vs. 8.5 ± 3.6 μm (P < 0.019, for both).<h4>Conclusions</h4>Whole CT decreased after PDT, including in medial areas from optic disc. This may be associated with the treatment response of PDT for CSC. |
| first_indexed | 2024-04-09T21:41:40Z |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T21:41:40Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-d043fcfb647541f3b5fd2c97f6bacc5a2023-03-26T05:31:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182e028205710.1371/journal.pone.0282057Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy.Ryoh FunatsuShozo SonodaHiroto TerasakiHideki ShiiharaNaohisa MiharaJuun HorieTaiji Sakamoto<h4>Purpose</h4>To explore the effect of photodynamic therapy (PDT) on the choroid of medial area from optic disc and factors correlated with treatment outcomes, we evaluated choroidal changes using ultra-widefield optical coherence tomography (UWF-OCT) after PDT for central serous chorioretinopathy (CSC).<h4>Methods</h4>In this retrospective case-series, we included CSC patients who received a standard-dose of full-fluence PDT. UWF-OCT were examined at baseline and 3 months after treatment. We measured choroidal thickness (CT), classified into central, middle, and peripheral sectors. We examined CT changes after PDT by sectors and treatment outcome.<h4>Results</h4>Twenty-two eyes of 21 patients (20 males; mean age 58.7 ± 12.3 years) were included. CT reduction after PDT was significant in all sectors, including peripheral areas: supratemporal, 330.5 ± 90.6 μm vs. 237.0 ± 53.2 μm; infratemporal, 240.0 ± 89.4 μm vs. 209.9 ± 55.1 μm; supranasal, 237.7 ± 59.8 vs 209.3 ± 69.3 μm; infranasal, 172.6 ± 47.2 μm vs. 155.1 ± 38.2 μm (P < 0.001, for all). In patients with retinal fluid resolution, despite no apparent difference in baseline CT, there was more significant reduction after PDT in supratemporal and supranasal peripheral sectors, compared with patients without resolution: supratemporal, 41.9 ± 30.3 μm vs. -1.6 ± 22.7 μm; supranasal, 24.7 ± 15.3 μm vs. 8.5 ± 3.6 μm (P < 0.019, for both).<h4>Conclusions</h4>Whole CT decreased after PDT, including in medial areas from optic disc. This may be associated with the treatment response of PDT for CSC.https://doi.org/10.1371/journal.pone.0282057 |
| spellingShingle | Ryoh Funatsu Shozo Sonoda Hiroto Terasaki Hideki Shiihara Naohisa Mihara Juun Horie Taiji Sakamoto Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. PLoS ONE |
| title | Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. |
| title_full | Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. |
| title_fullStr | Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. |
| title_full_unstemmed | Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. |
| title_short | Effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy. |
| title_sort | effect of photodynamic therapy on choroid of the medial area from optic disc in patients with central serous chorioretinopathy |
| url | https://doi.org/10.1371/journal.pone.0282057 |
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