Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS
Human parvovirus B19 replicates in erythrocyte precursors. Usually, there are no apparent hematological manifestations. However, in individuals with high erythrocyte turnover, as in patients with sickle-cell disease and in the fetus, the infection may lead to severe transient aplasia and hydrops fet...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2003-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000200014&tlng=en |
| _version_ | 1818263115667603456 |
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| author | Sérgio Setúbal Maria Cristina Jorge-Pereira Anadayr Leite Martins de Sant'Anna Solange Artimos de Oliveira Anna Ricordi Bazin Jussara Pereira do Nascimento |
| author_facet | Sérgio Setúbal Maria Cristina Jorge-Pereira Anadayr Leite Martins de Sant'Anna Solange Artimos de Oliveira Anna Ricordi Bazin Jussara Pereira do Nascimento |
| author_sort | Sérgio Setúbal |
| collection | DOAJ |
| description | Human parvovirus B19 replicates in erythrocyte precursors. Usually, there are no apparent hematological manifestations. However, in individuals with high erythrocyte turnover, as in patients with sickle-cell disease and in the fetus, the infection may lead to severe transient aplasia and hydrops fetalis, respectively. In AIDS patients, persistent infection may result in chronic anemia. By contrast, in HIV-positive patients without AIDS the infection evolves as a mild exanthematous disease. Two clinical descriptions exemplify these forms of presentation. In the first, an AIDS patient presented with bone marrow failure that responded to immunoglobulin. In the second, an HIV-positive patient without AIDS had a morbilliform rash, and needed no treatment. Knowing that an AIDS patient has chronic B19 anemia lessens concern about drug anemia; protects the patient from invasive diagnostic maneuvers; and prevents the patient from disseminating the infection. In AIDS patients with pure red cell aplasia, a search for parvovirus B19 DNA in the serum or in the bone marrow is warranted. |
| first_indexed | 2024-12-12T19:13:53Z |
| format | Article |
| id | doaj.art-d044e6563f3f4834af8f0626057d4156 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T19:13:53Z |
| publishDate | 2003-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-d044e6563f3f4834af8f0626057d41562022-12-22T00:14:47ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492003-04-01362299302Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDSSérgio Setúbal0Maria Cristina Jorge-Pereira1Anadayr Leite Martins de Sant'Anna2Solange Artimos de Oliveira3Anna Ricordi Bazin4Jussara Pereira do Nascimento5Universidade Federal FluminenseInstituto Estadual de Hematologia Arthur de Siqueira CavalcantiInstituto Estadual de Hematologia Arthur de Siqueira CavalcantiUniversidade Federal FluminenseFundação Oswaldo CruzFundação Oswaldo CruzHuman parvovirus B19 replicates in erythrocyte precursors. Usually, there are no apparent hematological manifestations. However, in individuals with high erythrocyte turnover, as in patients with sickle-cell disease and in the fetus, the infection may lead to severe transient aplasia and hydrops fetalis, respectively. In AIDS patients, persistent infection may result in chronic anemia. By contrast, in HIV-positive patients without AIDS the infection evolves as a mild exanthematous disease. Two clinical descriptions exemplify these forms of presentation. In the first, an AIDS patient presented with bone marrow failure that responded to immunoglobulin. In the second, an HIV-positive patient without AIDS had a morbilliform rash, and needed no treatment. Knowing that an AIDS patient has chronic B19 anemia lessens concern about drug anemia; protects the patient from invasive diagnostic maneuvers; and prevents the patient from disseminating the infection. In AIDS patients with pure red cell aplasia, a search for parvovirus B19 DNA in the serum or in the bone marrow is warranted.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000200014&tlng=enErythema infectiosumSickle cell anemiaParvovirusPure red cell aplasiaAIDS |
| spellingShingle | Sérgio Setúbal Maria Cristina Jorge-Pereira Anadayr Leite Martins de Sant'Anna Solange Artimos de Oliveira Anna Ricordi Bazin Jussara Pereira do Nascimento Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS Revista da Sociedade Brasileira de Medicina Tropical Erythema infectiosum Sickle cell anemia Parvovirus Pure red cell aplasia AIDS |
| title | Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS |
| title_full | Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS |
| title_fullStr | Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS |
| title_full_unstemmed | Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS |
| title_short | Clinical presentation of parvovirus B19 infection in HIV-infected patients with and without AIDS |
| title_sort | clinical presentation of parvovirus b19 infection in hiv infected patients with and without aids |
| topic | Erythema infectiosum Sickle cell anemia Parvovirus Pure red cell aplasia AIDS |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000200014&tlng=en |
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