Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1
Abstract Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas remains elusive. Acyl–coenzyme A (CoA) synthetase long-chain family member 4 (Acsl4), a pivotal enzyme in t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Sprog: | English |
| Udgivet: |
Nature Publishing Group
2022-06-01
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| Serier: | Cell Death and Disease |
| Online adgang: | https://doi.org/10.1038/s41419-022-04997-1 |