Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1

Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1

Abstract Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas remains elusive. Acyl–coenzyme A (CoA) synthetase long-chain family member 4 (Acsl4), a pivotal enzyme in t...

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Bibliographische Detailangaben
Hauptverfasser: Zong Miao, Wei Tian, Yangfan Ye, Wei Gu, Zhongyuan Bao, Lei Xu, Guangchi Sun, Chong Li, Yiming Tu, Honglu Chao, Sin Man Lam, Ning Liu, Jing Ji
Format: Artikel
Sprache:English
Veröffentlicht: Nature Publishing Group 2022-06-01
Schriftenreihe:Cell Death and Disease
Online Zugang:https://doi.org/10.1038/s41419-022-04997-1

Online

https://doi.org/10.1038/s41419-022-04997-1

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