Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats

Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats

Activated macrophages play a vital role in rheumatoid arthritis (RA) pathophysiology. CD44 is an overexpressed receptor on activated macrophages that is a potential target site for RA treatment. In this study, we prepared hyaluronic acid (HA) coated acid-sensitive polymeric nanoparticles (HAPNPs) co...

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Bibliographic Details
Main Authors: Changhui Yu, Xiangyu Li, Yufei Hou, Xiangxue Meng, Deli Wang, Jiaxin Liu, Fengying Sun, Youxin Li
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
rheumatoid arthritis
dexamethasone
hyaluronic acid
PCADK
acid-sensitive
Online Access:http://www.mdpi.com/1420-3049/24/1/146

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