The variation among sites of protein structure divergence is shaped by mutation and scaled by selection
Protein structures do not evolve uniformly, but the degree of structure divergence varies among sites. The resulting site-dependent structure divergence patterns emerge from a process that involves mutation and selection, which may both, in principle, influence the emergent pattern. In contrast with...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Current Research in Structural Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665928X20300167 |
| _version_ | 1819276366851342336 |
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| author | María Laura Marcos Julian Echave |
| author_facet | María Laura Marcos Julian Echave |
| author_sort | María Laura Marcos |
| collection | DOAJ |
| description | Protein structures do not evolve uniformly, but the degree of structure divergence varies among sites. The resulting site-dependent structure divergence patterns emerge from a process that involves mutation and selection, which may both, in principle, influence the emergent pattern. In contrast with sequence divergence patterns, which are known to be mainly determined by selection, the relative contributions of mutation and selection to structure divergence patterns is unclear. Here, studying 6 protein families with a mechanistic biophysical model of protein evolution, we untangle the effects of mutation and selection. We found that even in the absence of selection, structure divergence varies from site to site because the mutational sensitivity is not uniform. Selection scales the profile, increasing its amplitude, without changing its shape. This scaling effect follows from the similarity between mutational sensitivity and sequence variability profiles. |
| first_indexed | 2024-12-23T23:39:05Z |
| format | Article |
| id | doaj.art-d04cf53a6d2a40ddaec39cef3c6b52ed |
| institution | Directory Open Access Journal |
| issn | 2665-928X |
| language | English |
| last_indexed | 2024-12-23T23:39:05Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Structural Biology |
| spelling | doaj.art-d04cf53a6d2a40ddaec39cef3c6b52ed2022-12-21T17:25:47ZengElsevierCurrent Research in Structural Biology2665-928X2020-01-012156163The variation among sites of protein structure divergence is shaped by mutation and scaled by selectionMaría Laura Marcos0Julian Echave1Instituto de Ciencias Físicas, Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Martín de Irigoyen 3100, 1650 San Martín, Buenos Aires, ArgentinaCorresponding author.; Instituto de Ciencias Físicas, Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Martín de Irigoyen 3100, 1650 San Martín, Buenos Aires, ArgentinaProtein structures do not evolve uniformly, but the degree of structure divergence varies among sites. The resulting site-dependent structure divergence patterns emerge from a process that involves mutation and selection, which may both, in principle, influence the emergent pattern. In contrast with sequence divergence patterns, which are known to be mainly determined by selection, the relative contributions of mutation and selection to structure divergence patterns is unclear. Here, studying 6 protein families with a mechanistic biophysical model of protein evolution, we untangle the effects of mutation and selection. We found that even in the absence of selection, structure divergence varies from site to site because the mutational sensitivity is not uniform. Selection scales the profile, increasing its amplitude, without changing its shape. This scaling effect follows from the similarity between mutational sensitivity and sequence variability profiles.http://www.sciencedirect.com/science/article/pii/S2665928X20300167Protein evolutionMutationSelectionBiophysical modelStructure divergenceSequence divergence |
| spellingShingle | María Laura Marcos Julian Echave The variation among sites of protein structure divergence is shaped by mutation and scaled by selection Current Research in Structural Biology Protein evolution Mutation Selection Biophysical model Structure divergence Sequence divergence |
| title | The variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| title_full | The variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| title_fullStr | The variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| title_full_unstemmed | The variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| title_short | The variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| title_sort | variation among sites of protein structure divergence is shaped by mutation and scaled by selection |
| topic | Protein evolution Mutation Selection Biophysical model Structure divergence Sequence divergence |
| url | http://www.sciencedirect.com/science/article/pii/S2665928X20300167 |
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