MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis
MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of ge...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2016-12-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/2706.pdf |
| _version_ | 1797419460617830400 |
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| author | Jieyu He Jun Zhao Wenbo Zhu Daxun Qi Lina Wang Jinfang Sun Bei Wang Xu Ma Qiaoyun Dai Xiaojin Yu |
| author_facet | Jieyu He Jun Zhao Wenbo Zhu Daxun Qi Lina Wang Jinfang Sun Bei Wang Xu Ma Qiaoyun Dai Xiaojin Yu |
| author_sort | Jieyu He |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and the DGCR8polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04–1.42]), as well as the DICER1 polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05–1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings. |
| first_indexed | 2024-03-09T06:47:38Z |
| format | Article |
| id | doaj.art-d04f2f2b037d4b55b408081e03f4f00e |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:47:38Z |
| publishDate | 2016-12-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-d04f2f2b037d4b55b408081e03f4f00e2023-12-03T10:33:44ZengPeerJ Inc.PeerJ2167-83592016-12-014e270610.7717/peerj.2706MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysisJieyu He0Jun Zhao1Wenbo Zhu2Daxun Qi3Lina Wang4Jinfang Sun5Bei Wang6Xu Ma7Qiaoyun Dai8Xiaojin Yu9Southeast University, Department of Public Health, Nanjing, ChinaNational Research Institute for Family Planning, Beijing, ChinaSoutheast University, Department of Public Health, Nanjing, ChinaNational Research Institute for Family Planning, Beijing, ChinaSoutheast University, Department of Public Health, Nanjing, ChinaSoutheast University, Department of Public Health, Nanjing, ChinaSoutheast University, Department of Public Health, Nanjing, ChinaNational Research Institute for Family Planning, Beijing, ChinaNational Research Institute for Family Planning, Beijing, ChinaSoutheast University, Department of Public Health, Nanjing, ChinaMicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and the DGCR8polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04–1.42]), as well as the DICER1 polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05–1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings.https://peerj.com/articles/2706.pdfMeta-analysisMicroRNA biogenesisCancer risk |
| spellingShingle | Jieyu He Jun Zhao Wenbo Zhu Daxun Qi Lina Wang Jinfang Sun Bei Wang Xu Ma Qiaoyun Dai Xiaojin Yu MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis PeerJ Meta-analysis MicroRNA biogenesis Cancer risk |
| title | MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis |
| title_full | MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis |
| title_fullStr | MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis |
| title_full_unstemmed | MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis |
| title_short | MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis |
| title_sort | microrna biogenesis pathway genes polymorphisms and cancer risk a systematic review and meta analysis |
| topic | Meta-analysis MicroRNA biogenesis Cancer risk |
| url | https://peerj.com/articles/2706.pdf |
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