Epigenetic role of micrornas in diabetic cardiomyopathy
Cardiovascular complications in diabetic individuals account for significant morbidity and mortality. Clinical and epidemiological studies have also shown significantly increased incidence and prevalence of cardiovascular complications in diabetes. Heart failure (HF) in diabetes in the absence of kn...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
| Subjects: | |
| Online Access: | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=2;spage=79;epage=85;aulast=Raut |
| _version_ | 1811220810778542080 |
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| author | Satish K Raut Akhilesh Kumar Madhu Khullar |
| author_facet | Satish K Raut Akhilesh Kumar Madhu Khullar |
| author_sort | Satish K Raut |
| collection | DOAJ |
| description | Cardiovascular complications in diabetic individuals account for significant morbidity and mortality. Clinical and epidemiological studies have also shown significantly increased incidence and prevalence of cardiovascular complications in diabetes. Heart failure (HF) in diabetes in the absence of known cardiac complications such as myocardial infarction and coronary artery disease further supports the existence of diabetic cardiomyopathy (DbCM). Myocyte hypertrophy and myocardial fibrosis are the established pathological features of the DbCM and are associated with differential expression of genes involved in cardiac hypertrophy and fibrosis. Recent studies show the role of tiny noncoding regulatory RNAs, known as microRNAs (miRs), in the transcriptional and post-transcriptional regulation of gene expression. A large number of miRs have been identified that regulate diverse aspects of cardiac development and function and also play key role in regulating various signaling pathways involved in the pathogenesis of HF. The present review provides an overview of the role of miRs in diabetes-associated heart disease. |
| first_indexed | 2024-04-12T07:48:11Z |
| format | Article |
| id | doaj.art-d0500bd643244920828e82bd7d64a4c1 |
| institution | Directory Open Access Journal |
| issn | 2395-5414 2454-2830 |
| language | English |
| last_indexed | 2024-04-12T07:48:11Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj.art-d0500bd643244920828e82bd7d64a4c12022-12-22T03:41:39ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302016-01-0122798510.4103/2395-5414.191519Epigenetic role of micrornas in diabetic cardiomyopathySatish K RautAkhilesh KumarMadhu KhullarCardiovascular complications in diabetic individuals account for significant morbidity and mortality. Clinical and epidemiological studies have also shown significantly increased incidence and prevalence of cardiovascular complications in diabetes. Heart failure (HF) in diabetes in the absence of known cardiac complications such as myocardial infarction and coronary artery disease further supports the existence of diabetic cardiomyopathy (DbCM). Myocyte hypertrophy and myocardial fibrosis are the established pathological features of the DbCM and are associated with differential expression of genes involved in cardiac hypertrophy and fibrosis. Recent studies show the role of tiny noncoding regulatory RNAs, known as microRNAs (miRs), in the transcriptional and post-transcriptional regulation of gene expression. A large number of miRs have been identified that regulate diverse aspects of cardiac development and function and also play key role in regulating various signaling pathways involved in the pathogenesis of HF. The present review provides an overview of the role of miRs in diabetes-associated heart disease.http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=2;spage=79;epage=85;aulast=RautDiabetesdiabetic cardiomyopathymicroRNA |
| spellingShingle | Satish K Raut Akhilesh Kumar Madhu Khullar Epigenetic role of micrornas in diabetic cardiomyopathy Journal of the Practice of Cardiovascular Sciences Diabetes diabetic cardiomyopathy microRNA |
| title | Epigenetic role of micrornas in diabetic cardiomyopathy |
| title_full | Epigenetic role of micrornas in diabetic cardiomyopathy |
| title_fullStr | Epigenetic role of micrornas in diabetic cardiomyopathy |
| title_full_unstemmed | Epigenetic role of micrornas in diabetic cardiomyopathy |
| title_short | Epigenetic role of micrornas in diabetic cardiomyopathy |
| title_sort | epigenetic role of micrornas in diabetic cardiomyopathy |
| topic | Diabetes diabetic cardiomyopathy microRNA |
| url | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2016;volume=2;issue=2;spage=79;epage=85;aulast=Raut |
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