Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach
Health-related quality of life (HRQOL) is an important prognostic patient-reported outcome in oncology. Because prior studies suggest that HRQOL is, in part, heritable, we performed a GWAS to elucidate genetic factors associated with HRQOL in breast cancer survivors. Physical and mental HRQOL were m...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/4/716 |
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| author | Araba A. Adjei Camden L. Lopez Daniel J. Schaid Jeff A. Sloan Jennifer G. Le-Rademacher Charles L. Loprinzi Aaron D. Norman Janet E. Olson Fergus J. Couch Andreas S. Beutler Celine M. Vachon Kathryn J. Ruddy |
| author_facet | Araba A. Adjei Camden L. Lopez Daniel J. Schaid Jeff A. Sloan Jennifer G. Le-Rademacher Charles L. Loprinzi Aaron D. Norman Janet E. Olson Fergus J. Couch Andreas S. Beutler Celine M. Vachon Kathryn J. Ruddy |
| author_sort | Araba A. Adjei |
| collection | DOAJ |
| description | Health-related quality of life (HRQOL) is an important prognostic patient-reported outcome in oncology. Because prior studies suggest that HRQOL is, in part, heritable, we performed a GWAS to elucidate genetic factors associated with HRQOL in breast cancer survivors. Physical and mental HRQOL were measured via paper surveys that included the PROMIS-10 physical and mental health domain scales in 1442 breast cancer survivors participating in the Mayo Clinic Breast Disease Registry (MCBDR). In multivariable regression analyses, age and financial concerns were significantly associated with global physical health (age: <i>p</i> = 1.6 × 10<sup>−23</sup>; financial concerns: <i>p</i> = 4.8 × 10<sup>−40</sup>) and mental health (age: <i>p</i> = 3.5 × 10<sup>−7</sup>; financial concerns: <i>p</i> = 2.0 × 10<sup>−69)</sup>. Chemotherapy was associated with worse global mental health (<i>p</i> = 0.01). In the GWAS, none of the SNPs reached the genome-wide association significance threshold of 5 × 10<sup>−8</sup> for associations with either global physical or global mental health, however, a cluster of SNPs in <i>SCN10A</i>, particularly rs112718371, appeared to be linked to worse global physical health (<i>p</i> = 5.21 × 10<sup>−8</sup>). Additionally, SNPs in <i>LMX1B, SGCD, PARP12</i> and <i>SEMA5A</i> were also moderately associated with worse physical and mental health (<i>p</i> < 10<sup>−6</sup>). These biologically plausible candidate SNPs warrant further study as possible predictors of HRQOL. |
| first_indexed | 2024-03-09T04:54:33Z |
| format | Article |
| id | doaj.art-d0526b12e53040ed999a21fc9fcf301b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:54:33Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d0526b12e53040ed999a21fc9fcf301b2023-12-03T13:07:08ZengMDPI AGCancers2072-66942021-02-0113471610.3390/cancers13040716Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study ApproachAraba A. Adjei0Camden L. Lopez1Daniel J. Schaid2Jeff A. Sloan3Jennifer G. Le-Rademacher4Charles L. Loprinzi5Aaron D. Norman6Janet E. Olson7Fergus J. Couch8Andreas S. Beutler9Celine M. Vachon10Kathryn J. Ruddy11Department of Oncology, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Laboratory Medicine and Pathology, Rochester, MN 55905, USADepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USADepartment of Oncology, Mayo Clinic, Rochester, MN 55905, USAHealth-related quality of life (HRQOL) is an important prognostic patient-reported outcome in oncology. Because prior studies suggest that HRQOL is, in part, heritable, we performed a GWAS to elucidate genetic factors associated with HRQOL in breast cancer survivors. Physical and mental HRQOL were measured via paper surveys that included the PROMIS-10 physical and mental health domain scales in 1442 breast cancer survivors participating in the Mayo Clinic Breast Disease Registry (MCBDR). In multivariable regression analyses, age and financial concerns were significantly associated with global physical health (age: <i>p</i> = 1.6 × 10<sup>−23</sup>; financial concerns: <i>p</i> = 4.8 × 10<sup>−40</sup>) and mental health (age: <i>p</i> = 3.5 × 10<sup>−7</sup>; financial concerns: <i>p</i> = 2.0 × 10<sup>−69)</sup>. Chemotherapy was associated with worse global mental health (<i>p</i> = 0.01). In the GWAS, none of the SNPs reached the genome-wide association significance threshold of 5 × 10<sup>−8</sup> for associations with either global physical or global mental health, however, a cluster of SNPs in <i>SCN10A</i>, particularly rs112718371, appeared to be linked to worse global physical health (<i>p</i> = 5.21 × 10<sup>−8</sup>). Additionally, SNPs in <i>LMX1B, SGCD, PARP12</i> and <i>SEMA5A</i> were also moderately associated with worse physical and mental health (<i>p</i> < 10<sup>−6</sup>). These biologically plausible candidate SNPs warrant further study as possible predictors of HRQOL.https://www.mdpi.com/2072-6694/13/4/716health-related quality of lifegenome-wide association studyglobal physical and mental health |
| spellingShingle | Araba A. Adjei Camden L. Lopez Daniel J. Schaid Jeff A. Sloan Jennifer G. Le-Rademacher Charles L. Loprinzi Aaron D. Norman Janet E. Olson Fergus J. Couch Andreas S. Beutler Celine M. Vachon Kathryn J. Ruddy Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach Cancers health-related quality of life genome-wide association study global physical and mental health |
| title | Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach |
| title_full | Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach |
| title_fullStr | Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach |
| title_full_unstemmed | Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach |
| title_short | Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach |
| title_sort | genetic variations and health related quality of life hrqol a genome wide study approach |
| topic | health-related quality of life genome-wide association study global physical and mental health |
| url | https://www.mdpi.com/2072-6694/13/4/716 |
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